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Human Recombinant Heregulin Beta1 (from <i>E. coli</i>)

Human Recombinant Heregulin Beta1 (from E. coli)

Supplier:   Peprotech
Human Recombinant Heregulin Beta1 (from <i>E. coli</i>)
Supplier:  Peprotech
Certificates
Human Recombinant Heregulin Beta1 (from E. coli)
Specifications for Product Family Product Family Options
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Specifications for Product Family Product Family Options

6 Options Available Below

  • Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
  • Return Policy
Product Details & Documents

Neuregulin/Heregulin is a family of structurally related polypeptide growth factors derived from alternatively spliced genes (NRG1, NRG2, NRG3 and NRG4). To date, there are over 14 soluble and transmembrane proteins derived from the NRG1 gene. Proteolytic processing of the extracellular domain of the transmembrane NRG1 isoforms releases soluble growth factors. HRG1-β1 contains an Ig domain and an EGF-like domain; the latter is necessary for direct binding to receptor tyrosine kinases erb3 and erb4. This binding induces erb3 and erb4 heterodimerization with erb2, stimulating intrinsic kinase activity that leads to tyrosine phosphorylation. Although HRG1-β1's biological effects are still unclear, it has been found to promote motility and invasiveness of breast cancer cells, which may also involve up-regulation of expression and function of the autocrine motility-promoting factor (AMF). Recombinant Human Heregulinβ-1 (HRG1-B1) is a 7.5 kDa polypeptide consisting of only the EGF domain of heregulinβ-1 (65 amino acid residues). Manufactured using all Animal-Free reagents.

  • Carrier free
  • Animal-free

SHLVKCAEKE KTFCVNGGEC FMVKDLSNPS RYLCKCPNEF TGDRCQNYVM ASFYKHLGIE FMEAE

Verified by N-terminal and Mass Spectrometry analyses (when applicable).

Ordering information: For research use only. Not for use in diagnostic or therapeutic procedures.

Specifications for Product Family

Specifications

Specifications

  • Catalog No:
  • 10777-946
  • 10777-948
  • 10777-950
  • 10777-952
  • 10777-954
  • 10777-956
  • Protein/peptide name:
  • Heregulin Beta1
  • Heregulin Beta1
  • Heregulin Beta1
  • Heregulin Beta1
  • Heregulin Beta1
  • Heregulin Beta1
  • Protein/peptide type:
  • Recombinant
  • Recombinant
  • Recombinant
  • Recombinant
  • Recombinant
  • Recombinant
  • Species:
  • Human
  • Human
  • Human
  • Human
  • Human
  • Human
  • Source:
  • E. coli
  • E. coli
  • E. coli
  • E. coli
  • E. coli
  • E. coli
  • Animal-free:
  • Y
  • Y
  • Y
  • Y
  • Y
  • Y
  • Endotoxin content:
  • <0.1 ng/μg of protein (<1 EU/μg).
  • <0.1 ng/μg of protein (<1 EU/μg).
  • <0.1 ng/μg of protein (<1 EU/μg).
  • <0.1 ng/μg of protein (<1 EU/μg).
  • <0.1 ng/μg of protein (<1 EU/μg).
  • <0.1 ng/μg of protein (<1 EU/μg).
  • Biological activity:
  • The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
  • The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
  • The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
  • The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
  • The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
  • The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
  • Purity:
  • Greater than 98% by SDS-PAGE gel and HPLC analyses.
  • Greater than 98% by SDS-PAGE gel and HPLC analyses.
  • Greater than 98% by SDS-PAGE gel and HPLC analyses.
  • Greater than 98% by SDS-PAGE gel and HPLC analyses.
  • Greater than 98% by SDS-PAGE gel and HPLC analyses.
  • Greater than 98% by SDS-PAGE gel and HPLC analyses.
  • Formulation:
  • Lyophilized
  • Lyophilized
  • Lyophilized
  • Lyophilized
  • Lyophilized
  • Lyophilized
  • Storage conditions:
  • −20 °C
  • −20 °C
  • −20 °C
  • −20 °C
  • −20 °C
  • −20 °C
  • Shipping temperature:
  • RT
  • RT
  • RT
  • RT
  • RT
  • RT

Specifications

Product Family Options

Product Information

  • Size
    Origin
    Availability
    Price
  • 10777-946
    10 µg
    US
    Log in for availability
    Log in for availability
    Each (10µG)
    Each (10µG) - $312.52
    $312.52
    Each (10µG)
       $312.52
    Minimum order quantity is 1
    Supplier Number: AF-100-03-10UG
    Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
    Specifications:
    More
    Specifications
    Cat. No.
    10777-946
    Protein/peptide name
    Heregulin Beta1
    Protein/peptide type
    Recombinant
    Species
    Human
    Source
    E. coli
    Animal-free
    Y
    Endotoxin content
    <0.1 ng/μg of protein (<1 EU/μg).
    Biological activity
    The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
    Purity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    Formulation
    Lyophilized
    Storage conditions
    −20 °C
    Shipping temperature
    RT
  • 10777-948
    50 µg
    US
    Log in for availability
    Log in for availability
    Each (50µG)
    Each (50µG) - $686.94
    $686.94
    Each (50µG)
       $686.94
    Minimum order quantity is 1
    Supplier Number: AF-100-03-50UG
    Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
    Specifications:
    More
    Specifications
    Cat. No.
    10777-948
    Protein/peptide name
    Heregulin Beta1
    Protein/peptide type
    Recombinant
    Species
    Human
    Source
    E. coli
    Animal-free
    Y
    Endotoxin content
    <0.1 ng/μg of protein (<1 EU/μg).
    Biological activity
    The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
    Purity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    Formulation
    Lyophilized
    Storage conditions
    −20 °C
    Shipping temperature
    RT
  • 10777-950
    100 µg
    US
    Log in for availability
    Log in for availability
    Each (100µG)
    Each (100µG) - $1,065.14
    $1,065.14
    Each (100µG)
       $1,065.14
    Minimum order quantity is 1
    Supplier Number: AF-100-03-100UG
    Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
    Specifications:
    More
    Specifications
    Cat. No.
    10777-950
    Protein/peptide name
    Heregulin Beta1
    Protein/peptide type
    Recombinant
    Species
    Human
    Source
    E. coli
    Animal-free
    Y
    Endotoxin content
    <0.1 ng/μg of protein (<1 EU/μg).
    Biological activity
    The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
    Purity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    Formulation
    Lyophilized
    Storage conditions
    −20 °C
    Shipping temperature
    RT
  • 10777-952
    250 µg
    US
    Log in for availability
    Log in for availability
    Each (250µG)
    Each (250µG) - $1,631.19
    $1,631.19
    Each (250µG)
       $1,631.19
    Minimum order quantity is 1
    Supplier Number: AF-100-03-250UG
    Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
    Specifications:
    More
    Specifications
    Cat. No.
    10777-952
    Protein/peptide name
    Heregulin Beta1
    Protein/peptide type
    Recombinant
    Species
    Human
    Source
    E. coli
    Animal-free
    Y
    Endotoxin content
    <0.1 ng/μg of protein (<1 EU/μg).
    Biological activity
    The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
    Purity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    Formulation
    Lyophilized
    Storage conditions
    −20 °C
    Shipping temperature
    RT
  • 10777-954
    500 µg
    US
    Log in for availability
    Log in for availability
    Each (500µG)
    Each (500µG) - $2,622.17
    $2,622.17
    Each (500µG)
       $2,622.17
    Minimum order quantity is 1
    Supplier Number: AF-100-03-500UG
    Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
    Specifications:
    More
    Specifications
    Cat. No.
    10777-954
    Protein/peptide name
    Heregulin Beta1
    Protein/peptide type
    Recombinant
    Species
    Human
    Source
    E. coli
    Animal-free
    Y
    Endotoxin content
    <0.1 ng/μg of protein (<1 EU/μg).
    Biological activity
    The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
    Purity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    Formulation
    Lyophilized
    Storage conditions
    −20 °C
    Shipping temperature
    RT
  • 10777-956
    1 mg
    US
    Log in for availability
    Log in for availability
    Each (1mg)
    Each (1mg) - $4,367.69
    $4,367.69
    Each (1mg)
       $4,367.69
    Minimum order quantity is 1
    Supplier Number: AF-100-03-1MG
    Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
    Specifications:
    More
    Specifications
    Cat. No.
    10777-956
    Protein/peptide name
    Heregulin Beta1
    Protein/peptide type
    Recombinant
    Species
    Human
    Source
    E. coli
    Animal-free
    Y
    Endotoxin content
    <0.1 ng/μg of protein (<1 EU/μg).
    Biological activity
    The ED50 was determined by the dose-dependent stimulation of the proliferation of human MCF-7 cells is ≤ 0.5 ng/ml, corresponding to a specific activity of ≥ 2 x 106 units/mg.
    Purity
    Greater than 98% by SDS-PAGE gel and HPLC analyses.
    Formulation
    Lyophilized
    Storage conditions
    −20 °C
    Shipping temperature
    RT
   
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