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Anti-FOXO1 Rabbit Polyclonal Antibody
Catalog #: 10341-176
Supplier:  Bioss
Price
$1,026.51
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Unit of Measure Each (100µl)
Item requires temperature control for storage and delivery with additional fees. It's not eligible for return due to safety and quality concerns. Consider requirements before purchasing.
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Specifications

  • Antibody type:
    Primary
  • Antigen name:
    Forkhead box protein O1
  • Clonality:
    Polyclonal
  • Gene ID:
    2308
  • Host:
    Rabbit
  • Isotype:
    IgG
  • Reactivity:
    Human
    Rat
    Mouse
  • Antigen symbol:
    FOXO1
  • Conjugation:
    Unconjugated
  • ImmunoChemistry:
    Yes
  • Western blot:
    Yes
  • Cross adsorption:
    No
  • Form:
    liquid
  • Antigen synonyms:
    FKHR
    Forkhead in rhabdomyosarcoma
    Forkhead box protein O1A
    FOXO1
  • Storage buffer:
    Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at -20°C for 12 months.
  • Storage temperature:
    Store at –20 °C for 12 months
  • Concentration:
    1 μg/μl
  • Shipping temperature:
    4°C
  • Immunogen:
    230-280/655
  • Purification:
    Purified by Protein A
  • Cat. no.:
    10341-176
  • Size:
    100 µL

Specifications

About this item

Transcription factor that is the main target of insulin signaling and regulates metabolic homeostasis in response to oxidative stress. Binds to the insulin response element (IRE) with consensus sequence 5'-TT[G/A]TTTTG-3' and the related Daf-16 family binding element (DBE) with consensus sequence 5'-TT[G/A]TTTAC-3'. Activity suppressed by insulin. Main regulator of redox balance and osteoblast numbers and controls bone mass. Orchestrates the endocrine function of the skeleton in regulating glucose metabolism. Acts synergistically with ATF4 to suppress osteocalcin/BGLAP activity, increasing glucose levels and triggering glucose intolerance and insulin insensitivity. Also suppresses the transcriptional activity of RUNX2, an upstream activator of osteocalcin/BGLAP. In hepatocytes, promotes gluconeogenesis by acting together with PPARGC1A and CEBPA to activate the expression of genes such as IGFBP1, G6PC and PCK1. Important regulator of cell death acting downstream of CDK1, PKB/AKT1 and SKT4/MST1. Promotes neural cell death. Mediates insulin action on adipose tissue. Regulates the expression of adipogenic genes such as PPARG during preadipocyte differentiation and, adipocyte size and adipose tissue-specific gene expression in response to excessive calorie intake. Regulates the transcriptional activity of GADD45A and repair of nitric oxide-damaged DNA in beta-cells. Required for the autophagic cell death induction in response to starvation or oxidative stress in a transcription-independent manner.

Recommended Dilutions: Western Blot: 1:100-1000; IHC-P: 1:100-500; IF(IHC-P): 1:50-200

Type: Primary
Antigen: FOXO1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat