Cyano columns are generally more polar than traditional alkyl silica columns. The functional groups are highly ordered, reducing steric hindrance for the solute. The modification also allows cation exchange activity, which is higher at neutral pH than in acidic conditions.

• High throughput at high flow rates
• The possibility of flow gradients
• Added column performance by column coupling
• A rigid monolithic structure for a longer lifetime
• Less matrix-sensitivity

Chromolith® CN columns are suitable for the separation of alkaloids, oils, flavonoids, glycols, fenols, phthalates, steroids and sulfonamides.