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Specifications
- Protein/peptide type:Recombinant
- Species:Human
- Size:10 µg
- Biological activity:≥1'500mU/mg protein.One unit is defined as the amount of enzyme that will hydrolyze 1µmol Z-Phe-Arg-AMC substrate (OmniCathepsin™ Fluorogenic Substrate, Prod. No. BML-P139) per min. at 37°C in 50mM sodium acetate, pH 5.5, containing 2.5mM EDTA, 0.01%
- Protein/peptide name:Cathepsin K
- Purity:>95% (SDS-PAGE)
- Concentration:0.023mg/ml
- Formulation:Liquid. In 50mM sodium acetate, pH 5.5, containing 50mM sodium chloride, 0.5mM EDTA and 5mM DTT.
- Cat. no.:89164-520
- Supplier No.:SE553-0010
Specifications
About this item
Highly active
Produced in insect cells. Purified as full-length proenzyme (see Prod. No. BML-SE367), then auto-activated at low pH.
Cathepsin K, a member of the papain family of cysteine proteases, acts upon proteins such as collagen, AL amyloid, kinin, and elastin. It is a lysosomal protease expressed primarily in osteoclasts, but also in other cell types such as macrophages. It functions in bone remodeling and is implicated in disease states such as osteoporosis, atherosclerosis, arthritis, and pycnodysostosis.