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Specifications
- Size:0.5 mg
- Protein/peptide name:IKK-NBD Peptide
- Purity:>95% (HPLC)
- Cat. no.:89161-290
- Supplier No.:P607-0500
Specifications
About this item
NF-kappaB inhibitor
The peptide consists of two domains - an antennapedia homeodomain that confers cell permeability and the T735 to E745 region of IKKbeta which is the NEMO binding domain (NBD). It is a selective inhibitor of NFkappaB activation. Blocks interaction of NEMO (an IKB complex regulatory protein) with the IkappaB kinase complex. The peptide (100 µM) inhibits E-selectin expression in human umbilical vein endothelial cells treated with TNFalpha and inhibits LPS-induced nitric acid release from a macrophage cell line In an experimental mouse model of acute inflammation, IKK-NBD peptide (topically applied) inhibited PMA induced ear inflammation. Sold under license from Vanderbilt University