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Anti-RANKL Mouse Monoclonal Antibody [clone: 12A668]
Anti-RANKL Mouse Monoclonal Antibody [clone: 12A668]
Catalog #: 89359-764
Supplier:  Genetex
Anti-RANKL Mouse Monoclonal Antibody [clone: 12A668]
Catalog #: 89359-764
Supplier:  Genetex
Price
$976.58
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Unit of Measure Each (100µG)
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Specifications

  • Antibody type:
    Primary
  • Antigen name:
    Receptor activator of nuclear factor kappa-B ligand
  • Clonality:
    Monoclonal
  • Clone:
    12A668
  • Gene ID:
    21943
  • Host:
    Mouse
  • Isotype:
    IgG1
  • Reactivity:
    Mouse
  • Antigen symbol:
    RANKL
  • Conjugation:
    Unconjugated
  • ImmunoChemistry:
    Yes
  • Size:
    100 μg
  • Western blot:
    Yes
  • Antigen synonyms:
    RANKLigand,
    Osteoprotegerin ligand,
    OPGL,
    sOdf,
    ODF,
    TRANCE,
    CD254,
    TNF-related activation-induced cytokine,
    RANKL,
    Receptor activator of nuclear factor kappa B ligand,
    hRANKL2,
    OPTB2
  • Storage buffer:
    PBS containing 0.05% BSA and 0.05% sodium azide was added as a preservative .
  • Storage temperature:
    Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
  • Concentration:
    0.5 mg/ml
  • Immunogen:
    Fusion protein, corresponding to amino acids 1-317 of Mouse sRANKL.
  • Tested applications:
    IHC, WB
  • Purification:
    Protein G purified
  • Cat. no.:
    89359-764

Specifications

About this item

sRANKL is a member of the tumor necrosis factor (TNF) cytokine family which is a ligand for osteoprotegerin and functions as a key factor for osteoclast differentiation and activation. This protein was shown to be a dentritic cell survival factor and is involved in the regulation of T cell-dependent immune response. T cell activation was reported to induce expression of this gene and lead to an increase of osteoclastogenesis and bone loss. This protein was shown to activate antiapoptotic kinase AKT/PKB through a signaling complex involving SRC kinase and tumor necrosis factor receptor-associated factor (TRAF) 6, which indicated this protein may have a role in the regulation of cell apoptosis.

We recommend the following starting dilutions:

For WB: Use at a concentration of 0.5-2 µg/ml.

For IHC-P: Use at a concentration of 5 µg/ml.

For FACS: Use at a assay dependent dilution.

Optimal dilutions should be determined experimentally by the end user.

Type: Primary
Antigen: RANKL
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Mouse

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