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Specifications
- Antibody type:Primary
- Antigen name:Receptor-interacting serine/threonine-protein kinase 3
- Antigen symbol:RIPK3
- Clonality:Monoclonal
- Clone:Rippy-3
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG1
- Reactivity:Human
- Western blot:Yes
- Size:50 μg
- Antigen synonyms:RIP-like protein kinase 3|Receptor-interacting protein 3|RIPK3|RIP-3|RIP3|Receptor-interacting serine/threonine-protein kinase 3
- Gene ID:11035
- Concentration:1 mg/ml
- Immunogen:Recombinant full length protein (Human).
- Purification:>95% by SDS-PAGE
- Storage buffer:Preservative: 0.02% Sodium Azide; Constituents: PBS
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Tested applications:WB
- Cat. no.:89360-154
- Supplier No.:GTX16090
Specifications
About this item
Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.
WB: Use at a concentration of 1 ?g/ml. Predicted molecular weight: 62 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.
Type: Primary
Antigen: RIPK3
Clonality: Monoclonal
Clone: Rippy-3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human