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Anti-RIPK3 Mouse Monoclonal Antibody [clone: Rippy-3]
Anti-RIPK3 Mouse Monoclonal Antibody [clone: Rippy-3]
Catalog #: 89360-154
Supplier:  Genetex
Anti-RIPK3 Mouse Monoclonal Antibody [clone: Rippy-3]
Catalog #: 89360-154
Supplier:  Genetex
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Specifications

  • Antibody type:
    Primary
  • Antigen name:
    Receptor-interacting serine/threonine-protein kinase 3
  • Clonality:
    Monoclonal
  • Clone:
    Rippy-3
  • Gene ID:
    11035
  • Host:
    Mouse
  • Isotype:
    IgG1
  • Reactivity:
    Human
  • Antigen symbol:
    RIPK3
  • Conjugation:
    Unconjugated
  • Size:
    50 μg
  • Western blot:
    Yes
  • Antigen synonyms:
    RIP-like protein kinase 3|Receptor-interacting protein 3|RIPK3|RIP-3|RIP3|Receptor-interacting serine/threonine-protein kinase 3
  • Storage buffer:
    Preservative: 0.02% Sodium Azide; Constituents: PBS
  • Storage temperature:
    Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
  • Concentration:
    1 mg/ml
  • Immunogen:
    Recombinant full length protein (Human).
  • Tested applications:
    WB
  • Purification:
    >95% by SDS-PAGE
  • Cat. no.:
    89360-154
  • Supplier No.:
    GTX16090

Specifications

About this item

Certain serine/threonine protein kinases, such as ASK1, RIP, DAP, and ZIP kinases, are mediators of apoptosis. Receptor interacting proteins including RIP and RIP2/RICK mediate apoptosis induced by TNFR1 and Fas, two prototype members in the death receptor family. A novel member in the RIP kinase family was recently identified and designated RIP3. RIP3 contains N-terminal kinase domain but, unlike RIP or RIP2, lacks the C-terminal death or CARD domain. RIP3 binds to RIP and TNFR1, mediates TNFR1 induced apoptosis, and attenuates RIP and TNFR1 induced NF-kB activation. Over expression of RIP3 induces apoptosis and NF-kB activation. The messenger RNA of RIP3 is expressed in a subset of adult tissues.

WB: Use at a concentration of 1 ?g/ml. Predicted molecular weight: 62 kDa. Not tested in other applications. Optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: RIPK3
Clonality: Monoclonal
Clone: Rippy-3
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG1
Reactivity: Human

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