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Anti-PRKCA Mouse Monoclonal Antibody [clone: 133]
Anti-PRKCA Mouse Monoclonal Antibody [clone: 133]
Catalog #: 89358-746
Supplier:  Genetex
Anti-PRKCA Mouse Monoclonal Antibody [clone: 133]
Catalog #: 89358-746
Supplier:  Genetex
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Specifications

  • Antibody type:
    Primary
  • Antigen name:
    Protein Kinase C, Alpha
  • Clonality:
    Monoclonal
  • Clone:
    133
  • Gene ID:
    5578
  • Host:
    Mouse
  • Isotype:
    IgG2a
  • Reactivity:
    Mammals
  • Antigen symbol:
    PRKCA
  • Conjugation:
    Unconjugated
  • ImmunoChemistry:
    Yes
  • Size:
    1 ml
  • Western blot:
    Yes
  • Antigen synonyms:
    PRKCE|Protein kinase C beta type|PKCG|PKCE|PRKCT|PRKCG|SDK1|PKC2|PKC-A|nPKC-zeta|nPKC-theta|Protein kinase C zeta type|Protein kinase C epsilon type|PRKACA|nPKC-epsilon|PKC-B|PRKCZ|Protein kinase C alpha type|nPKC-delta|PKC-alpha|PRKCA|PKC-beta|PRKCQ|PKCB|PKC-gamma|Protein kinase C theta type|Tyrosine-protein kinase PRKCD|Protein kinase C gamma type|Sphingosine-dependent protein kinase-1|Protein kinase C delta type|PRKCD|PRKCB|PKC zeta|PRKCB1|PKCA
  • Storage buffer:
    0.1%Sodium Azide
  • Storage temperature:
    Store at +4°C for one month or at -20°C for longer. This product should be stored undiluted. Avoid repeated freezing and thawing as this may denature the antibody. Should this product contain a precipitate we recommend microcentrifugation before use.
  • Immunogen:
    Protein kinase C alpha.
  • Tested applications:
    IHC-Fr, WB
  • Purification:
    Tissue Culture Supernatant
  • Cat. no.:
    89358-746
  • Supplier No.:
    GTX11723

Specifications

About this item

Protein Kinase c alpha (PKC alpha) is an 80 kDa member of the conventional group (cPKCs: sensitive to calcium, diacylglycerol, phosphatidylserine and phorbol esters) of the PKC family of serine/ threonine kinases that are involved in a wide range of physiological processes including mitogenesis, cell survival and transcriptional regulation. PKC alpha is an ubiquitously expressed PKC isozyme that has been implicated in the regulation of a broad range of cellular functions including proliferation, differentiation, development, migration, cell-cell adhesion, cell extracellular matrix adhesion, and solute transport. The activation loop threonine (threonine 497 in PKC alpha) of conventional PKCs is phosphorylated by phosphoinositide-dependent kinase-1 (PDK1). This phosphorylation is necessary for the autophosphorylation of threonine 638 in the carboxy-terminus of PKC alpha, a step that is critical for regulating the rate of PKC alpha dephosphorylation and inactivation.

Recommended Starting Dilutions:Immunohistology - Frozen: Neat - 1/10Western Blotting: 1/10 - 1/500Not tested in other applications. Optimal dilution / concentration should be determined by the end user.

Type: Primary
Antigen: PRKCA
Clonality: Monoclonal
Clone: 133
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human, Mouse, Mammals

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