Order Entry
ContactUsLinkComponent
Anti-HMGB1 Mouse Monoclonal Antibody
Anti-HMGB1 Mouse Monoclonal Antibody
Catalog #: 89359-736
Supplier:  Genetex
Anti-HMGB1 Mouse Monoclonal Antibody
Catalog #: 89359-736
Supplier:  Genetex
Restricted Products: To process your orders without delay, please provide the required business documentation to purchase this product.

To order chemicals, medical devices, or other restricted products please provide ID that includes your business name & shipping address via email [email protected] or fax 484.881.5997 referencing your VWR account number. Acceptable forms of ID are:

  • • State issued document with your organization's Federal Tax ID Number
  • • State issued document with your organization's Resale Tax ID Number
  • • City or County issued Business License
  • • State Department of Health Services License
  • • Any other ID issued by the State that includes the business name & address

* ATTN: California Customers may require additional documentation as part of the CA Health & Safety Code. Products that fall under this regulation will be placed on a mandatory 21-day hold after documentation is received. VWR will not lift restrictions for residential shipping addresses.

Specifications

  • Antibody type:
    Primary
  • Antigen name:
    High-mobility Group Box 1
  • Clonality:
    Monoclonal
  • Host:
    Mouse
  • Isotype:
    IgG2a
  • Reactivity:
    Human
  • Antigen symbol:
    HMGB1
  • Conjugation:
    Unconjugated
  • Western blot:
    Yes
  • Antigen synonyms:
    high-mobility group box 1|RP11-550P23.1|high mobility group protein 1|Amphoterin|SBP-1|high-mobility group (nonhistone chromosomal) protein 1|high mobility group protein B1|HMG3|Sulfoglucuronyl carbohydrate binding protein|HMG1|HMG-1
  • Storage buffer:
    Phosphate-bufferd saline
  • Storage temperature:
    Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
  • Immunogen:
    Pig HMGB1
  • Tested applications:
    WB
  • Purification:
    Protein A purified
  • Cat. no.:
    89359-736
  • Supplier No.:
    GTX13540

Specifications

About this item

HMG1 and HMG2, chromatin non-histone high mobility group proteins 1 and 2, are 27 and 25 kDa members of a family of proteins containing multiple HMG-boxes, conserved domains of 80 amino acids which mediate DNA binding of many proteins. HMG box domains recognize DNA structure, such as prebent, supercoiled or four way junction DNA, and non- specific DNA sequences. Both HMG1 and HMG2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMG1/2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites, such as steroid hormone receptors, p53, and Oct. HMG1/2 may serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription and replication.

Type: Primary
Antigen: HMGB1
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human

Customers Who Bought This Also Bought