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Specifications
- Antibody type:Primary
- Antigen name:High-mobility Group Box 1
- Antigen symbol:HMGB1
- Clonality:Monoclonal
- Conjugation:Unconjugated
- Host:Mouse
- Isotype:IgG2a
- Reactivity:Human
- Western blot:Yes
- Antigen synonyms:high-mobility group box 1|RP11-550P23.1|high mobility group protein 1|Amphoterin|SBP-1|high-mobility group (nonhistone chromosomal) protein 1|high mobility group protein B1|HMG3|Sulfoglucuronyl carbohydrate binding protein|HMG1|HMG-1
- Immunogen:Pig HMGB1
- Purification:Protein A purified
- Storage buffer:Phosphate-bufferd saline
- Storage temperature:Keep as concentrated solution. Store at 4 °C short term. For extended storage aliquot and store at –20 °C or below. Avoid freeze-thaw cycles.
- Tested applications:WB
- Cat. no.:89359-736
- Supplier No.:GTX13540
Specifications
About this item
HMG1 and HMG2, chromatin non-histone high mobility group proteins 1 and 2, are 27 and 25 kDa members of a family of proteins containing multiple HMG-boxes, conserved domains of 80 amino acids which mediate DNA binding of many proteins. HMG box domains recognize DNA structure, such as prebent, supercoiled or four way junction DNA, and non- specific DNA sequences. Both HMG1 and HMG2 contain an N-terminal HMG box, a central HMG box, and an acidic carboxy terminus. The acidic tails of these proteins contain multiple serine residues which match the phosphorylation consensus sites of casein kinase II, and phosphorylation of this domain appears to be important for proper functioning of these proteins. HMG1/2 have been shown to facilitate the binding of various sequence-specific transcription factors to their respective DNA binding sites, such as steroid hormone receptors, p53, and Oct. HMG1/2 may serve as architectural factors that recognize and mediate DNA structural changes that accompany various events such as DNA repair, transcription and replication.
Type: Primary
Antigen: HMGB1
Clonality: Monoclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2a
Reactivity: Human