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Vaccines Downstream Processing

During subsequent steps for vaccine concentration and clarification, followed by passage through several filtration steps and chromatography columns, it is critical that vaccine purity, potency, and consistency be maintained.

Vaccines Downstream Processing | Avantor

Ensuring vaccine quality

For mammalian systems where the target vaccine is secreted into the culture medium and then processed through similar steps (except lysis) the same holds true for ensuring vaccine quality. To achieve this, our offering of stability, low-pH, low salt/high salt, equilibration, elution buffers, and individual buffer components is ideal.

Lastly, when removing recombinant baculovirus via chemical inactivation in an insect expression system, J.T.Baker® and VWR detergents should also be considered. Dilution of detergent activity is achieved by the dilution using buffers.

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Discover Avantor's fluid handling solutions and access literature, technical articles and videos.


With cGMP and cGDP chemical and excipients manufacturing, see how Avantor’s offerings can help speed time-to-market.


Learn how Avantor Services bioprocessing specialists can help optimize your upstream and downstream operations.


Browse Avantor’s J.T.Baker® brand products designed to optimize every step of downstream processing.


From pre-clinical through commercial manufacturing, Avantor works closely with biopharmaceutical customers to reduce downstream optimization turnaround times so biopharmaceutical customers can reach the market faster with new therapeutics.

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