Large Molecule LC (Bio LC)
The separation of active ingredients that have been manufactured using biological processes often requires a different approach. Multiple chromatographic techniques are employed to fully characterize these complex biomolecules. Due to their size and nature, they are inherently more difficult to separate. Monoclonal antibodies, antibody-drug conjugates and some peptides require different techniques and a different approach when it comes to separation. Luckily, products from Avantor® can help.
Questions about our chromatography products for your large molecule LC (Bio LC) analysis?
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Large Molecule LC (Bio LC) Products
A U/HPLC column with 300Å pore size (or larger) and a C4 or C8 ligand is suitable for small proteins and large peptides. Proteins are retained by adsorbtion of the hydrophobic foot.
If you are looking for a reliable range of chromatographic media, manufactured under cGMP conditions that can fulfill your needs from lab to production scale, Avantor® has a wide choice.