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Column Selection | Avantor

Column Selection

Selecting the correct column is key to your success. There are thousands of columns to choose from. How can you be sure that you choose the correct one? Avantor® is here to help you find the right column for your needs.

How do we support chromatography users? With a range of techniques including analytical HPLC and UHPLC, sample preparation and preparative HPLC, we can help you to determine the best HPLC column chemistry and dimension for your needs. We can help you get the best from your sample preparation to improve your results and keep you up-to-date with the latest instrument and software developments. We also have a growing range of gas chromatography products and services. We can offer service solutions tailored to your needs with everything from HPLC and GC instrument maintenance to HPLC method development and training.


Questions about how to select the right column?

Contact us today for expert technical advice and to discuss your sample preparation, LC and GC needs. Our team is ready to help at [email protected]

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Column Selection Products and Resources


Want to learn more about the different stationary phase options available? We have a summary here to help you select the right one for your analysis. There is also a guide to which separation made maybe best which is determined by analyte molecular size and polarity.


If you are looking for unique stationary phases for complex separations, take a look at these novel stationary phases of the Avantor® ACE® range.


Avantor® are pleased to offer expert Applications support. Contact us to discuss your method challenges and we can offer advice and support using our inhouse knowledge and resources.

Featured Chromatography Solutions


Solve your chromatography challenges with an extensive portfolio of HPLC and UHPLC columns and consumables designed to meet all of your separation needs. Thermo Scientific (U)HPLC columns offer an unmatched variety of chemistries, from the most popular C18 phases, to innovative mixed-mode chemistries, to the broadest range of solid core columns on the market and more.


When selecting the most suitable GC column it is necessary to consider the polarity of the stationary phase and the analytes. You can see that different columns have different polarities suitable for a wide range of volatile sample mixtures.

Reversed phase is the most popular and versatile mode in LC. For hydrophobic compounds, this mode is preferable.

If you have a racemic mixture of enantiomers, chiral chromatography is the process of separating enantiomers from each other.

If you have compounds that are weakly retained by RP phases, HILIC could be a useful alternative.

Size exclusion chromatography separates analytes based on their molecular weight and shape.

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