12531 Resultaten voor: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

Phenobarbital is well established as a potent inducer of cytochrome P-450 2B (CYP2B) expression, and work by different groups has shown that AP-1 might play a role in the induction process, and that insulin is able to supress the effect of phenobarbital. Human CYP2B6 appears to be the primary enzyme involved in the N-demethylation of S-mephenytoin and may contribute to the hepatic metabolism of toluene to benzyl alcohol.

Supplier: Enzo Life Sciences

Recommended Applications: IF, IHC (FS)

Species reactivity: Human, Sheep

Supplier: Enzo Life Sciences

Recommended Applications: IHC

Species reactivity: Rodent

Supplier: Enzo Life Sciences

Human cytochrome P-450 2D6 (CYP2D6) is responsible for the metabolism of many psychotherapeutic drugs, and has been shown to act on MPTP a thermal product of synthetic heroin, which causes Parkinson's Disease (PD)-like symptoms in man. Mutation in the cyp2D6 gene has been reported to be associtated with PD. The association between Parkinson's Disease and genetic polymorphism in the human CYP2D6 gene has been reported. CYP2D6 has been found in first trimester human fetal liver, and in the placenta. Rat CYP2D1, the homolgue of human CYP2D6, has been shown to catalyse the conversion of hydrocodone to hydromorphone, and in rat liver microsomes it participates in the conversion of ethylmorphine to codeine and morphine.

Supplier: Enzo Life Sciences

Cell permeable non-tubulin-interacting mitosis inhibitor. Blocks mitosis (IC50=14µM) by binding to the mitotic kinesin Eg5.

Supplier: Enzo Life Sciences

HDAC inhibitor

Supplier: Enzo Life Sciences

Vitronectin is a plasma glycoprotein that circulates in the blood as a mixture of both 75kDa and 65kDa forms. Vitronectin is a major cell adhesive glycoprotein, and a common component of extracellular matrix and plasma. It competes effectively with other plasma proteins, and often participates in cell attachment, regulation of blood coagulation and immune responses. It has similar tissue distribution to fibronectin, which is recognized by its integrin receptor.

Supplier: Enzo Life Sciences

Complement factor C9 is a 71kDa single-chain ellipsoid a-globular molecule of 558 amino acids including a leader sequence of 20 amino acids. C9 binds the C5b8 complex on membranes and has the unique function of forming tubular structures containing between 12 and 18 monomers, closely resembling the membrane attack complex (MAC). The primary site of synthesis is hepatocytes; secondary sites are monocytes, fibroblasts and glial cells. The normal level of C9 in plasma is 60 µg/ml, and the level is upregulated from hepatocytes by IFN-γ.

Supplier: Enzo Life Sciences

L-Ficolin (Ficolin-2) is an innate immunity pattern recognition molecule found in human serum. L-Ficolin binds to distinct pathogen-associated molecular patterns (PAMP) such as carbohydrates (GlcNAc), lipoteichoic acid and acetylated groups, thereby facilitating phagocytosis and activation of complement through the lectin route using the same serine proteases as mannose-binding lectin (MBL) named MASP (MBL-associated serine protease).

Supplier: Enzo Life Sciences

Endogenous [1] ligand for the CB1 receptor (CB1: Ki=52nm; CB2: Ki=1930nm [2]) and TRPV1 (Ki=5.78µM [3,4]). Inhibits NF-κB activation through direct binding to IKKβ [5] and induces apoptosis independently of cannabinoid or vanilloid receptors [6]. Activates the MAP kinase (MAPK/ERK) signalling pathway [7].

Supplier: Enzo Life Sciences

Cannabinoid receptor ligand.

Supplier: Enzo Life Sciences

Unsaturated analog of endogenous sleep inducing lipid.

Supplier: Enzo Life Sciences

Cannabinoid receptor ligand.

Supplier: Enzo Life Sciences

Stable and water-soluble derivative of hyperforin inducing apoptosis. Antitumor agent. Inhibits sirtuins.

Supplier: Enzo Life Sciences

Produced in SF21 cells. Fused to a His-tag.

Supplier: Enzo Life Sciences

PKA inhibitor

Supplier: Enzo Life Sciences

Produced in E. coli. Catalytic domain of human minor vault p193 protein (aa 220-574) is fused at the C-terminus to a His-tag.

Supplier: Enzo Life Sciences

Enzyme regulation and kinetics, comparative studies of substrate or inhibitor specificities, cleavage of target proteins. Assay or digest conditions can vary widely, but concentrations for the MMP enzymes can range between 10 and 300nM, or higher. Reaction temperatures can be between 25 and 37 °C, and reaction times can range from 10 min to overnight, again depending on application and substrate. A typical assay buffer is 50 mM HEPES, pH 7,0, 10 mM CaCl₂, 0,05% Brij-35. For more information, contact Enzo Life Sciences Technical Support.

Supplier: Enzo Life Sciences

Based on the dye cresyl violet and the cathepsin B ArgArg peptide recognition sequence, this kit allows the detection of cathepsin B activity in living cells by fluorescence microscopy.

Supplier: Enzo Life Sciences

Fluorescent substrates plus inhibitors to greatly increase sensitivity. Mainly used for Fluorescent detection and HTS activity assay.

Supplier: Enzo Life Sciences

Isolated from human plasma as prothrombin, and activated with Factor Xa, Factor Va, phospholipids, and calcium to yield a-thrombin.

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ADP-ribosylation factor inhibitor

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A QuantiZyme™ Assay System. The MMP-1 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-1 (MMP-1, interstitial collagenase, fibroblast collagenase) using a thiopeptide as a chromogenic substrate.

Supplier: Enzo Life Sciences

Anti-PARP1 Mouse Monoclonal Antibody [clone: C-2-10]

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG2b

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Host: Mouse, Isotype: IgG2b

Supplier: Enzo Life Sciences

FAAH substrate.