12531 Resultaten voor: "ENZO LIFE SCIENCES"

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Antibiotic. Apoptosis inducer.

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X-Gal (5-bromo-4-chloro-3-indolyl-ß-D-galactopyranoside)

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Zinc dye

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Plant H+-ATPase activator.

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Host: Mouse, Isotype: IgG1

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PAF receptor antagonist. Inhibits PAF-induced human platelet and neutrophil aggregation in vitro (IC50=0.17 and 0.36µM respectively). In vivo it dose dependently blocks eosinophil activation and displays antiallergic and anti-inflammatory activity in various models. Induces differentiation and triggers apoptosis and in a variety of cell lines.

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NALP3 ligand

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Ceramide-activated protein kinase activator.

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Antioxidant and chemopreventive

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Induces cell differentiation.

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PPARδ agonist.

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Methyltransferase inhibitor

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Produced in HEK 293 cells. The extracellular domain of human BAFF-R (aa 2-71) is fused at the C-terminus to the Fc portion of human IgG1.

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Ultra-pure; inhibits actin polymerization

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Host: Mouse, Isotype: IgG1

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AMPIGENE® DNA ladder contains DNA fragments ranging from 50 bp to 1500 bp that can be used as molecular weight standards for agarose gel electrophoresis. The bands are evenly spaced and are intensified at 200 bp, 500 bp and 1500 bpto serve as easily identifiable reference bands. The approximate mass of DNA in each of the bands is provided, assuming 5 µl load, for determining the approximate mass of DNA in samples with comparable intensity and sizes.

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Nitric oxide (NO) donor.

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The polo-like kinases (PLKs) function in cell-cycle progression and in multiple stages of mitosis. PLK1 is activated by phosphorylation of Thr210 at the G2/M phase boundary. Active PLK1 participates in mitotic entry through activation of Cdc25C and nuclear import of cyclin B1, thereby activating the Cdc2/cyclin B kinase.

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URB-597 is a potent and selective inhibitor of the enzyme fatty acid amide hydrolase (FAAH), which is involved in the hydrolysis of endogenous cannabinoids such as anandamide. Inhibition of FAAH may serve to enhance the analgesic effects of endogenous cannabinoids. URB-597 has been shown to inhibit FAAH in rat cortical neuron membranes and in intact neurons with IC50 values of 4.6nM and 0.5nM, respectively. The compound has also been shown to have anxiolytic effects in rats (ID50=0.15mg/kg). Because URB-597 acts on FAAH and does not interfere with the binding of anandamide to the CB1 and CB2 receptors, it is a novel tool for drug development.

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Highly specific, potent, irreversible, and cell-permeable competitive inhibitor of proprotein convertases: furin/SPC1 (Ki~1 nM), SPC2/PC2 (Ki=0.36nM), SPC3/PC1/PC3(Ki= 2,0nM), SPC4/PACE4 (Ki=3,6 nM), SPC6/PC5/PC6, and SPC7/LPC/PC7/PC8 (Ki=0,12 nM). Because furin activates viral glycoproteins, this inhibitor is a useful antiviral agent. In addition, it inhibits furin-dependent pro-MMP-2 activation in various cell lines, including U87 and HT1080 cells. Typical concentration range used in tissue culture is 25 to100 µm.

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For the quantitative determination of human Cu/Zn SOD in cell culture supernatants, serum and other body fluids.

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For increased cell permeability the peptide was covalently linked to the 10 aa recognized by the TAT transporter.

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The first selective PDE7 inhibitor (Ki=180 nM).

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Calcium dye

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Ultra-pure; inhibits actin polymerization

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AGT inhibitor

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Blocks glucosylation of ceramide by inhibiting UDP-glucose:ceramide glucosyltransferase (glucosylceramide synthetase). Inhibits the expression of cell surface glycolipid antigens and inhibits the growth of cultured rabbit skin fibroblasts. Possesses antitumor activity and inhibits Lewis lung carcinoma cell metastasis in vitro. Useful tool for studying the effects of cellular glycosphingolipid depletion. Enhances the apoptotic response to ionizing radiation by enhancing the ceramide signal.

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A guggul tree steroid well known for its lipid lowering properties. Acts as a selective antagonist at farnesoid X receptors (FXRs). Inhibits FXR transactivation (IC50=10µM).

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SOD (Superoxide dismutase) is responsible for the elimination of cytotoxic active oxygen by catalyzing the dismutation of the superoxide radical to oxygen and hydrogen peroxide. There are three SOD isoenzymes in mammalian cells, they are: EC SOD (extracellular SOD), Cu/Zn SOD (copper and zinc-containing SOD) and Mn SOD (manganese-containing SOD).

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Host: Rabbit