12531 Resultaten voor: "ENZO LIFE SCIENCES"
Anti-HSPA8 Mouse Monoclonal Antibody (DyLight® 488) [clone: N27F3-4]
Supplier: ENZO LIFE SCIENCES
The Hsp70 family of heat shock protiens contains multiple homologs ranging in size from 66-78 kDa, and are the eukaryotic equivalents of the bacterial DnaK. The most studied Hsp70 members include the cytosolic stress-induced Hsp70 (Hsp72), the constitutive cytosolic Hsc70 (Hsp73), and the ER-localized BiP (Grp78). Hsp70 family members contain highly conserved N-terminal ATP-ase and C-terminal protein binding domains. Binding of peptide to Hsp70 is assisted by Hsp40, and stimulates the inherent ATPase activity of Hsp70, facilitating ATP hydrolysis and enhanced peptide binding. Hsp70 nucleotide exchange and substrate binding coordinates the folding of newly synthesized proteins, the re-folding of misfolded or denatured proteins, coordinates trafficking of proteins across cellular membranes, inhibits protein aggregation, and targets the degradation of proteins via the proteasomal pathway.
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Arg8-vasopressin ELISA kit
Supplier: ENZO LIFE SCIENCES
Highly sensitive ELISA kit for the detection of Arg8-Vasopressin in serum, plasma and tissue culture media.
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Why Choose Corning Fetal Bovine Serum?
Our vertically integrated FBS serum supply chain, from collection to scientist, allows us to provide a consistent supply of FBS.
Epigenetics library, Screen-Well®
Supplier: ENZO LIFE SCIENCES
The Screen-Well® epigenetics library contains 43 compounds with defined activity against enzymes which carry out epigenetic modification of lysine. It also includes DNA methylation inhibitors. Compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates at 100 µl or 500 µl per well. The library is a useful tool for chemical genomics, assay development and other pharmacological applications. The library contains inhibitors of these important enzymes: HDACs, SIRTs, Lysine demethylases, HATs, Histone methyl transferases, DNA methyltransferases as well as SIRT activators. A variety of structurally and mechanistically different compound classes are included.
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NGAL (mouse) ELISA kit
Supplier: ENZO LIFE SCIENCES
For the quantitative determination of NGAL in mouse urine, plasma, serum, tissue extracts, or culture supernatants.
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Palmityltrifluoromethylketone ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Inhibitor of both Ca2+-dependent cytosolic cPLA2 (IC50=45 µM) and Ca2+-independent phospholipases A2 iPLA2 (IC50=3.8 µM).
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AMPIGENE® HS Taq DNA Polymerase
Supplier: ENZO LIFE SCIENCES
Increased sensitivity standard PCR for a broader range of samples, with enhanced speed, yield, and specificity.
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Anti-CANX Rabbit Polyclonal Antibody
Supplier: ENZO LIFE SCIENCES
Calnexin (CNX), an unglycosylated resident ER transmembrane protein, together with Calreticulin (CRT), plays a key role in glycoprotein folding and its control within the ER, by interacting with folding intermediates via their monoglucosylated glycans. Calnexin associates with newly synthesized monomeric glycoproteins and only recognizes glycoproteins when they are incompletely folded. Furthermore, Calnexin has been demonstrated to function as a molecular chaperone capable of interacting with polypeptide segments of folding glycoproteins.
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IL-2 (human), ELISA kit
Supplier: ENZO LIFE SCIENCES
The IL-2 (human), EIA kit is a colorimetric immunometric enzyme immunoassay kit with results in 3 hours.
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Lovastatin ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
HMG-CoA reductase inhibitor
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D-erythro-Sphingosine ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
Common component of cell membranes, often as phosphatidyl conjugates. Is a potent (IC50=1-3 µM) and selective inhibitor of protein kinase C. Inhibition is competitive with diacylglycerol, phorbol dibutyrate and Ca2+ and it also inhibits PKC activation by other lipids. It acts on an equimolar basis with 1,2-dioleoylglycerol and does not affect other kinases such as MLCK and PKA. It is active in intact cells and has been identified as an endogenous constituent in HL-60 cells, neutrophils, rat liver, and brain and mouse tissues. Other activities include inhibition of phosphatidate phosphohydrolase, Na+,K+-ATPase, CTP:phosphocholine cytidylyltransferase, calmodulin-dependent enzymes, binding of factor VII to tissue factor, binding of thyrotropin releasing hormone to its receptor and activation of EGF receptor kinase, phospholipase D and casein kinase II.
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Ko143 ≥96% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Analog of the fungal toxin fumitremorgin C. Potent and selective inhibitor of the breast cancer resistance protein multidrug transporter (BCRP, EC90=26nM). Highly effective for increasing the intracellular drug accumulation and reversing BCRP-mediated multidrug resistance yet has little activity against P-glycoprotein, multidrug resistance-associated protein (MRP1) and other known drug transporters. In mouse models Ko143 was able to restore the intracellular accumulation and abolish the directionality in net flux of dasatinib. It is a highly useful tool for the identification of drug transport processes in complex experimental systems.
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Sheep Cyclooxygenase (from Seminal vesicles)
Supplier: ENZO LIFE SCIENCES
Isolated from ram seminal vesicles.
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Mouse recombinant BAFF (soluble)
Supplier: ENZO LIFE SCIENCES
Produced in HEK 293 cells. The extracellular domain of mouse BAFF (aa 127-309) is fused at the N-terminus to a linker peptide (10 aa) and a FLAG®-tag.
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Rat Recombinant Omentin
Supplier: ENZO LIFE SCIENCES
Produced in HEK 293 cells. Rat omentin (aa 20-313) is fused at the N-terminus to a FLAG®-tag.
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Tyrphostin AG-126 ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES
AG-126 prevents lipopolysaccharide-induced lethal toxicity (septic shock) in mice. Administered at 1.5 mg/mouse, it reduced LPS-induced lethal toxicity from 95% to 10%. AG-126 greatly reduces LPS-induced tyrosine phosphorylation of p42MAPK in murine peritoneal macrophages at 50 µM. EGFR, Her-2/neu receptor or PDGF-R are not inhibited at 100 µM. Inhibits tyrosine kinase-dependent B cell receptor signaling.
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Human recombinant Caspase-4 (from E. coli)
Supplier: ENZO LIFE SCIENCES
Produced in E. coli.
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SC-236 ≥95% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Highly selective and potent inhibitor of cyclooxygenase-2 (IC50=10nM for COX-2 versus IC50=17.8µM for COX-1) with antitumor properties. Exhibits longer half-life time and reduced gastric toxicity in fasting rat model. Has antitumor properties and has been shown to induce apoptosis and bFGF and VEGF-driven angiogenesis. Potent antimetastatic activity against both spontaneous metastases arising following primary tumour excision and experimental metastases.
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MBCQ ≥98%
Supplier: ENZO LIFE SCIENCES
Selective inhibitor of cGMP-specific phosphodiesterase (PDE V, IC50=19 nM).
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Leukotriene E4 ≥98% (by HPLC)
Supplier: ENZO LIFE SCIENCES
Prostanoid receptor ligand.
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BML-244 ≥98% (by TLC)
Supplier: ENZO LIFE SCIENCES
A highly potent, cell-permeable inhibitor of cathepsin K (IC50=51 nM).
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Mouse recombinant adiponectin
Supplier: ENZO LIFE SCIENCES
Mouse adiponectin (aa 18-247) is fused at the N-terminus to a linker peptide (8 aa) and a FLAG®-tag.