12530 Resultaten voor: "ENZO LIFE SCIENCES"

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The ryanodine receptor (RyR) is the channel responsible for the release of calcium from the sarcoplasmic reticulum (SR) in muscle cells and also plays a role in calcium regulation in non-muscle cells. The RyR exists as a homotetramer and is predicted to have a short cytoplasmic C-terminus and 4-10 transmembrane domains; the remainder of the protein, termed the "foot" region is located in the cytoplasm between the T-tubule and the SR. The mammalian RyR is the product of three different genes: RyR-1, which is expressed predominantly in skeletal muscle and areas of the brain, RyR-2, which is expressed predominantly in the heart muscle but also found in the stomach, endothelial cells and diffuse areas of the brain, and RyR-3 which is found in smooth muscle and the brain (striatum, thalamus and hippocampus).

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Host: Mouse, Isotype: IgG2a

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Cathepsin inhibitor

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mGluR agonist

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Host: Rabbit

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Host: Rabbit

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Inhibitor of prostaglandin and leukotriene synthesis.

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Receptor tyrosine kinase (RTK) inhibitor

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Host: Rabbit

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mGluR agonist

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Host: Rabbit

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Host: Rabbit

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Fas ligand

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Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.

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Osteopontin (OPN) is an acidic extracellular matrix cell adhesion protein that is relatively abundant not only in bone matrix, plasma, urine, and milk, but is also found in malignant and atherogenic tissues. Phosphorylation, glycosylation and calcium modifications allow intact and fragmented Osteopontin to direct a variety of diverse responses including tissue remodeling, inflammation and cell survival. Plasma Osteopontin has been shown to provide prognostic information in breast, prostate, colon, and lung cancers as well as metastatic carcinomas. The notable presence of Osteopontin in a variety of tumors is strongly correlated to pathological stage, suggesting its critical role in tumor invasiveness, progression and metastasis. In addition, Osteopontin inhibits inducible nitric oxide synthase activity, thereby protecting tumor cells from NO-mediated macrophage cytotoxic attack. Osteopontin is found in atherosclerotic plaques and may drive a number of diabetic vascular pathologies.

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Host: Rabbit

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Produced in HEK 293 cells. The cysteine-rich domain of human NGFR (nerve growth factor receptor; p75NTR) (aa 1-250) is fused to the Fc portion of human IgG1.

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Produced in HEK 293 cells. The cysteine-rich region of human DR3 (aa 25-199) is fused to the Fc portion of human IgG1.

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Produced in E. coli. Human IL-1β (interleukin-1β) (aa 117-270) is fused to a linker peptide (10 aa) and an N-terminal FLAG®-tag.

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Host: Mouse, Isotype: IgG2a

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Host: Human, Isotype: IgG1

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Host: Mouse, Isotype: IgG1

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Host: Rat, Isotype: IgG2a

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BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.

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Host: Mouse, Isotype: IgG1

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TLR4 activator.

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Host: Mouse, Isotype: IgG2a

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Host: Rabbit

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Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit