Specifications
- Type antilichaam:Primair
- Clonality:Polyklonaal
- Conjugatie:Alexa Fluor® 680
- Host:Rabbit
- ImmunoChemie:Yes
- ImmunoFluorescentie:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Western blot:Yes
- Epitoop:21-120/259
- Formulier:Liquid
- Gen-ID:4869
- Antigeen synoniemen:NPM|Numatrin|Nucleophosmin|Nucleolar protein NO38|B23|Nucleolar phosphoprotein B23|NPM1
- Modification:Unmodified
- Opslagbuffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Moleculair gewicht:33 kDa
- Opslagtemperatuur:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentratie:1 µg/µl
- Shipping temperature:4 °C
- Immunogeen:KLH conjugated synthetic peptide derived from human Nucleophosmin
- Tested applications:ICC
- Purification:Purified by Protein A
- Verpakking:Vial
- VPE:100 µl
Specifications
About this item
Involved in diverse cellular processes such as ribosome biogenesis, centrosome duplication, protein chaperoning, histone assembly, cell proliferation, and regulation of tumor suppressors p53/TP53 and ARF. Binds ribosome presumably to drive ribosome nuclear export. Associated with nucleolar ribonucleoprotein structures and bind single-stranded nucleic acids. Acts as a chaperonin for the core histones H3, H2B and H4. Stimulates APEX1 endonuclease activity on apurinic/apyrimidinic (AP) double-stranded DNA but inhibits APEX1 endonuclease activity on AP single-stranded RNA. May exert a control of APEX1 endonuclease activity within nucleoli devoted to repair AP on rDNA and the removal of oxidised rRNA molecules. In concert with BRCA2, regulates centrosome duplication. Regulates centriole duplication: phosphorylation by PLK2 is able to trigger centriole replication. Negatively regulates the activation of EIF2AK2/PKR and suppresses apoptosis through inhibition of EIF2AK2/PKR autophosphorylation.
Type: Primary
Antigen: Nucleophosmin
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 21-120/259
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat