- Type antilichaam:Primair
- antigeen symbool:DDX58
- Clonality:Polyklonaal
- Conjugatie:FITC (Fluoresceïne-isothiocyanaat)
- Host:Rabbit
- ImmunoChemie:Yes
- Isotype:IgG
- Reactivity:Human,Mouse
- Kruisadsorptie:No
- Formulier:liquid
- Gen-ID:23586
- Antigeen synoniemen:Probable ATP-dependent RNA helicase DDX58|DEAD box protein 58|RIGI|RIG-I|RIG-1|RLR-1
- Modification:phospho-Thr170
- Opslagbuffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Opslagtemperatuur:Store at 4°C for 12 months
- Concentratie:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- VPE:100 µl
The innate immune system detects viral infection by recognizing various viral components and triggers antiviral responses. Like the toll-like receptor 3 (TLR3), the cytoplasmic helicase retinoic acid inducible gene protein 1 (RIG1/DDX58) recognizes double-stranded (ds) RNA, a molecular pattern associated with viral infection. Unlike TLR3 however, RIG1/DDX58 activates the kinases TBK1 and IKKe through the adaptor protein IPS1. These kinases then phosphorylate the transcription factors IRF3 and IRF7 which are essential for the expression of type-I interferons. RIG1/DDX58 is required for the production of interferons in response to RNA viruses including paramyxoviruses, influenza virus, and Japanese encephalitis virus.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: DDX58
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse