Specifications
- Type antilichaam:Primair
- antigeen symbool:DNM1
- Clonality:Polyklonaal
- Conjugatie:FITC (Fluoresceïne-isothiocyanaat)
- Host:Rabbit
- ImmunoChemie:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Kruisadsorptie:No
- Formulier:liquid
- Gen-ID:1759
- Antigeen synoniemen:EC 3.6.5.5|DNM1|Dynamin BREDNM19|DNM|brain|dynamin-1|Dynamin|B-dynamin|D100
- Opslagbuffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Opslagtemperatuur:Store at 4°C for 12 months
- Concentratie:1 μg/μl
- Shipping temperature:4°C
- Purification:Purified by Protein A
- VPE:100 µl
Specifications
About this item
Dynamin I is a GTPase enzyme required for the retrieval of synaptic vesicles after exocytosis and functions in endocytosis by stimulating assembly of invaginating synaptic vesicles (1). Dynamin I is phosphorylated in nerve terminals exclusively in the cytosolic compartment and in vitro by protein kinase C (PKC) (2–5). The phosphorylation site in PKC-phosphorylated Dynamin I is a single site at Serine 795, which is located near a binding site for the SH3 domain of p85, the regulatory subunit of phosphatidylinositol 3-kinase (2–5). Dephosphorylation is required for synaptic vesicle retrieval, suggesting that phosphorylation affects the subcellular localization of Dynamin I (5). Mouse, rat and human Dynamin I are phosphorylated on serine residues, including Ser 778, by Cdk5, regulating PACSIN1 recruitment and enabling synaptic vesicle endocytosis.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: DNM1
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat