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Novel approaches to antibody-drug-conjugate (ADC) analysis

Webinar

Tuesday, 23rd April, 2024 
15:00 to 16:00 CET (Berlin, Paris, Madrid)

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 Novel approaches to antibody-drug-conjugate (ADC) analysis | Avantor
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Antibody-drug-conjugates (ADCs) are cancer biotherapeutics in which monoclonal antibodies specifically bind tumour cells and the conjugated cytotoxic payload is responsible for causing cancer cell death.

The combination of a small molecule to a protein poses additional challenges to their analysis.

This webinar will present (U)HPLC-based methods for ADC-characterisation: Drug-to-antibody-ratio (DAR) by an improved hydrophobic interaction chromatography (HIC) column, analysis of aggregated ADC and residual payload by size exclusion chromatography (SEC) and the use of a unique affinity-based method to characterise ADCs. 

For more information, please contact us at [email protected]

Presented By:

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Andrea Krumm

Andrea Krumm studied biotechnology before gaining a PhD in cell- and cancer-biology. After four years as an applications specialist for optical analytical devices used in academic and pharmaceutical research, she joined Tosoh Bioscience GmbH in 2020 as a product manager for analytical columns. As such she is responsible for gathering customer requirements, application areas and addressing these with new and existing products of the analytical columns line and Tosoh’s Multi-Angle-Light-Scattering Detector LenS3.