1529 Résultats pour : "single-use assemblies"

Supplier: Biosensis

FUNCTION: Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization.  SUBCELLULAR LOCATION: Cytoplasm; cytosol. Cell membrane. Mostly found in the axons of neurons, in the cytosol and in association with plasma membrane components. ALTERNATIVE PRODUCTS: 8 named isoforms produced by alternative splicing. Additional isoforms seem to exist. Isoforms differ from each other by the presence or absence of up to 5 of the 15 exons. One of these optional exons contains the additional tau/MAP repeat. TISSUE SPECIFICITY: Expressed in neurons. Isoform PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system. DEVELOPMENTAL STAGE: Four-repeat (type II) tau is expressed in an adult-specific manner and is not found in fetal brain, whereas three-repeat (type I) tau is found in both adult and fetal brain. DOMAIN: The tau/MAP repeat binds to tubulin. In Alzheimer disease, the neuronal cytoskeleton in the brain is progressively disrupted and replaced by tangles of paired helical filaments  and straight filaments, mainly composed of hyperphosphorylated forms of Microtubule-associated protein Tau. Defects in Microtubule-associated protein Tau are a cause of frontotemporal dementia and parkinsonism linked to chromosome 17, as well as a number of other neurodegenerative diseases.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2b antibody against human, mouse, rat GFAP (glial fibrillary acidic protein), unconjugated.

Supplier: CAPITAL SAFETY

The DBI-SALA® Confined space HC (high capacity) short reach davit system is constructed of powder-coated aluminium, and features a modular design for easy transport and storage. The system is adjustable, providing flexibility during installation.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG2a antibody against human, mouse, rat beta-tubulin III, unconjugated.

Supplier: NEW PIG

Chemical Mat that quickly absorbs acids, caustics and unknown liquids for effective clean-up of high volume spills.

Supplier: UVEX

The uvex C500 series sets standards regarding protection, comfort, flexibility, tactility and economy. This high-tech safety glove combines all of these qualities with the highest level of cut protection, level 5/C.

Supplier: SIGMA ALDRICH MICROSCOPY

Immersion Oil has a defined refractive index of about 1,516. It is important that the refractive index (nD) is about 1,5, similar to that of glass. This enables a homogeneous oil immersion to be achieved.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against mouse, rat nestin, unconjugated.

Supplier: Avantor Fluid Handling

Pump at pressures up to 125 psi (8.5 bar).

Supplier: ProSci Inc.

SSB is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. SSB protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome and systemic lupus erythematosus.La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus La is involved in diverse aspects of RNA metabolism, including binding and protecting 3-prime UUU (OH) elements of newly RNA polymerase III (see MIM 606007)-transcribed RNA, processing 5-prime and 3-prime ends of pre-tRNA precursors, acting as an RNA chaperone, and binding viral RNAs associated with hepatitis C virus. La protein was originally defined by its reactivity with autoantibodies from patients with Sjogren syndrome (MIM 270150) and systemic lupus erythematosus (SLE; MIM 152700) (Teplova et al., 2006 [PubMed 16387655]).[supplied by OMIM]. Sequence Note: removed 1 base from the 3' end that did not align to the reference genome assembly. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications. PRIMARYREFSEQ_SPAN PRIMARY_IDENTIFIER PRIMARY_SPAN COMP 1-1673 BC020818.1 1-1673

Supplier: Cytiva

La conception modulaire simple de la cuve d'électrophorèse verticale miniVE regroupe toutes les petites sections de l'électrophorèse et du buvardage dans une seule unité pratique. La température homogène du gel est maintenue avec le réservoir tampon inférieur de type cuve. Une cuve pleine stabilise la température afin que les séries soient droites et les bandes plates. Le module de buvardage supporte deux gels/piles de membrane simultanément. Le réservoir tampon inférieur est conçu pour contenir deux modules de buvardage, ce qui permet d'accueillir quatre gels à buvarder simultanément.

Supplier: asecos

Armoires de sécurité ignifugées, type 90 (résistant au feu durant 90 minutes).

Supplier: Corning

Culture thousands of spheroids in a T-75 footprint.

Supplier: Ansell

The HyFlex® 11-731 glove features an 18G ultralight weight, medium-duty liner with INTERCEPT TECHNOLOGY® yarns that provide ISO Cut Level B protection for high levels of cut resistance.

Supplier: MP Biomedicals

MPure-32™ aNAP System is a fully automated magnetic bead-based nucleic acid extraction system. It can process up to 32 samples simultaneously within a short period of time (around 40 to 60 minutes). Besides its capability to extract nucleic acid with high purity and yield, MPure-32™ aNAP System is easy to use; this eliminates the risk of human error and cross-contamination.

Supplier: asecos

Fireproof safety cabinets, classified type 90 (fire resistant up to 90 minutes), safe and approved storage of flammable hazardous substances in working areas.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, PE-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, PerCP-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, unconjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, APC­-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, FITC-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, biotin-conjugated.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, PerCP-Cy5.5-conjugated

Supplier: Showa

Showa S-TEX 376 durable double-dipped nitrile coated glove that provides resistance to oil whilst protecting from cuts and lacerations. Ideal for the secure handling of oily components and materials that present a high degree of mechanical risk. Manufactured with SHOWA's patented Hagane Coil® technology.

Supplier: Ansell

Innovative multi-layer chemical barrier technology, type 3/4/5 protection.

Supplier: STEMCELL Technologies

Mouse monoclonal IgG1 antibody against human, chimpanzee CD3, Alexa Fluor® 488-conjugated

Supplier: Cytiva

Amersham™ Protran® Supported is a robust protein blotting membrane, with 0,2 µm pore size, made of reinforced nitrocellulose for multiple reprobings.

Supplier: Thermo Fisher Scientific

GeneJET™ Whole Blood Genomic DNA Purification Mini Kit utilises silica-based membrane technology in the form of a convenient spin column, eliminating the need for expensive resins, toxic phenol-chloroform extractions, or time-consuming alcohol precipitation. The standard procedure takes less than 20 minutes following cell lysis and yields purified DNA greater than 30 kb in size. Isolated DNA can be used directly in PCR, Southern blotting, and enzymatic reactions.

Supplier: ProSci Inc.

BAFF is mainly produced by innate immune cells such as neutrophils, monocytes, macrophages, dendritic cells, follicular dendritic cells. T cells, activated B cells, some malignant B cells and also non-lymphoid cells like astrocytes, synoviocytes and epithelial cells can also produce BAFF. BAFF binds three distinct receptors (BAFF-R, TACI and BCMA) expressed predominantly on B cells, although activated T cells also express BAFF-R. BAFF is a master regulator of peripheral B cell survival, and together with IL-6, promotes Ig class-switching and plasma cell differentiation. Besides its major role in B cell biology, BAFF co-stimulates activated T cells. Deregulated expression of BAFF leads to autoimmune disorders in mice. In humans, elevated levels of soluble BAFF have been detected in the serum of patients with various autoimmune diseases such as Sjoegren syndrome, Rheumatoid arthritis (RA), Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE). BAFF has also increased levels in some lymphoid cancers. Processed human BAFF can either remain as a trimer, which is usual for TNF family ligands or assemble into 60-mer composed of 20 trimers. Mouse BAFF 60-mer has been identified in the serum of BAFF transgenic mice. Oligomerisation of BAFF 3-mer into 60-mer in human BAFF is prevented by mutation of His218, a residue critical for 3-mer-to-3-mer interactions, but not for receptor binding. Despite the predominant functional role of processed BAFF in vivo, membrane-bound BAFF might also play a role. Indeed, soluble BAFF (3-mer) can trigger BAFF-R but not TACI or BCMA, whereas oligomeric forms of BAFF (BAFF 60-mer), which mimic membrane-bound BAFF, activate all BAFF receptors.

Supplier: UVEX

These Dyneema®Diamond Technology/polyamide/elastane gloves feature a knitted cuff and an aqua-polymer foam coating on palm and fingertips that provides very good mechanical abrasion resistance. These safety gloves are like a second skin and are especially light and flexible – without making your hands immediately sweaty.