12531 Résultats pour : "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Recommended Applications: ELISA, IHC, IP, WB

Species reactivity: Human, Hamster, Cat

Supplier: Enzo Life Sciences

Recommended Applications: IP, Immunopurification

Species reactivity:

Supplier: Enzo Life Sciences

Bilobalide is a terpenoid isolated from Ginkgo biloba. It has been proposed to exert trophic and protective effects on neurons. It increases the sensitivity of mouse pancreatic β cells to glucose and displays protective effects during hypoxia.

Supplier: Enzo Life Sciences

LPA receptor ligand

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PKC activator

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Produced in E. coli. The catalytic domain of human DEP-1 (aa 1024-1306) is fused at the N-terminus to a GST-tag.

Supplier: Enzo Life Sciences

Produced in E. coli. Active Matrix Metalloproteinase-11 (MMP-11, Stromelysin-3) catalytic domain from human cDNA.

Supplier: Enzo Life Sciences

Inhibitor of TNF-alpha processing

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Caspase inhibitor

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Wnt pathway activator

Supplier: Enzo Life Sciences

DKK1 inhibitor

Supplier: Enzo Life Sciences

Express DNA Methylation Kit can be used for rapid and reliable bisulfite treatment and conversion of DNA for methylation analysis.

Supplier: Enzo Life Sciences

LYSO-ID® Green Detection Kit is an acidic organelle-selective dye specially designed to use with RFP-expressing cell lines, as well as cells expressing blue, cyan or orange fluorescent proteins (BFPs, CFPs, OFPs).

Supplier: Enzo Life Sciences

The Rab family of GTP-binding proteins are members of the Ras superfamily of small G proteins, and participate in multiple steps of the membrane trafficking. Rab3A participates in the fusion of synaptic vesicles during neurotransmitter release, a process regulated by GDP/GDP exchange cofactors such as GAP, GDI, GRF, and rabphilin. Rab4 regulates recycling of proteins from the early endosome to the surface of many cell types, regulating glucose transporter and transferrin receptor cell surface localization. Rab5 regulates the fusion of plasma membrane-derived clathrin-coated vesicles with early endosomes and homotypic fusion among early endosomes.

Supplier: Enzo Life Sciences

Synapse-associated proteins SAP97 and SAP102 display extensive sequence homology to the PSD 95 family of proteins that facilitate ion channel clustering at synaptic terminals. In addition to the CNS, SAP97 is also detected at the basal lateral membrane between a variety of epithelial cells. SAP102 associates with NMDA receptors through the C-terminal NR2B subunit of the receptor. The N-terminal SAP97 PDZ domain mediates its interaction with the synaptic ras-GTPase activating protein SynGAP.

Supplier: Enzo Life Sciences

PGD2 is a principal metabolite of arachidonic acid, catalyzed by PGD synthases primarily in hematopoietic and neural cells. Although PGD2 is traditionally considered a pro-inflammatory mediator, the actions of PGD2 and its metabolites have been shown to exert concentration-dependent pro- and anti-inflammatory effects on leukocyte development, function, and apoptosis.

Supplier: Enzo Life Sciences

Produced in E. coli. Human BAG-1M is fused at the N-terminus to a His-tag.

Supplier: Enzo Life Sciences

Anti-GRP78 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

Chloride dye

Supplier: Enzo Life Sciences

Cysteine string protein (CSP) is a 34 kDa rat brain protein localized to the cytoplasmic surface of the synaptic vesicle. CSP is believed to perform similar functions in the assembly of synaptic vesicle proteins which are essential to membrane trafficking.

Supplier: Enzo Life Sciences

PARP5a inhibitor

Supplier: Enzo Life Sciences

MEK is a dual specificity kinase capable of phosphorylating both tyrosine and threonine residues. The MEK family, which is also known as MAP kinase kinase, phosphorylates MAP kinases on the conserved T-X-Y motif; phosphorylation of MAPK by MEK results in an increase in MAPK activity. MEK is involved in a diverse array of cellular processes such as stress-activated response, apoptosis, cytokine-induced cell proliferation, and DNA recombination during meiosis.

Supplier: Enzo Life Sciences

The Akt (PKB) family of protein kinases are serine/threonine kinases, with three mammalian family members identified (Akt1, Akt2, Akt3). Akt is a well-characterized member of PI3 kinase-mediated signaling pathways, regulating cell growth, apoptosis, glycogen synthesis, and other cellular responses through its phosphorylation of downstream substrates. Akt activation is triggered by binding of phospholipid and phosphorylation at two key residues: Thr308 by PDK1, and Ser473 by PDK2, now identified as mTOR. Deregulation of Akt signaling has been associated with cancer, diabetes, and schizophrenia. Akt1 is the cellular homologue of the murine thymoma retroviral oncogene v-akt, and its role in anti-apoptotic and pro-mitotic pathways have made Akt a molecular target for anti-cancer therapeutic intervention. Akt activation inhibits apoptosis by phosphorylating the Bcl-2 related protein Bad, and increases p53 degradation by phosphorylating mdm2. Mitotic substrates of Akt include GSK-3β, p21CIP1, and p27KIP1, cell cycle inhibitors negatively regulated by Akt phosphorylation. Akt has been shown to mediate angiogenesis through regulation of thrombospondins, which may cooperate with pro-mitotic and anti-apoptotic functions of Akt to promote tumorigenesis.

Supplier: Enzo Life Sciences

Produced in E. coli. Mouse Dkk-1 is fused at the N-terminus to a His-tag.

Supplier: Enzo Life Sciences

Produced in E. coli. Untagged USP2 catalytic domain.

Supplier: Enzo Life Sciences

The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands.

Supplier: Enzo Life Sciences

The Jurkat T lymphocyte cell line was established from the peripheral blood of a 14-year old boy with T cell leukaemia.

Supplier: Enzo Life Sciences

Beclin-1 is a coiled-coil Bcl-2-interacting protein that functions in autophagy, the process of bulk degradation of cellular proteins. Beclin-1 is homologous to the yeast autophagy gene apg6, and is expressed at reduced levels in human breast carcinoma, suggesting that defects in autophagy proteins may contribute to the development or progression of tumors. Bcl-2 can inhibit Beclin-1-dependent autophagy in yeast and mammalian cells, suggesting that Bcl-2 functions as both an anti-autophagic and anti-apoptotic protein.

Supplier: Enzo Life Sciences

Produced in E. coli. Human αA-Crystallin is fused at the N-terminus to a His-tag.