Nicotinamide ≥99% PARP inhibitor

Amide form of vitamin B₃. Plasma membrane and blood-brain barrier permeable. Precursor for β-nicotinamide adenine dinucleotide (NAD+). Essential for the synthesis of NAD+ phosphate (NADP+). Essential for energy metabolism, normal physiology and disease progression. Associated with a number of signaling pathways including oxidative stress, cell survival and inflammation. These effects are orchestrated partly through forkhead, Akt, Bad, caspase, MAPK and PARP signaling. Non-selective sirtuin inhibitor. Commonly used as 3D growth matrix components and additive for long-term growth.

Attention: All products are FOR RESEARCH USE ONLY. PRODUCTS ARE NOT FOR USE IN DIAGNOSTIC OR THERAPEUTIC PROCEDURES. Customer is granted a limited use non-exclusive licence for its own internal research. Any control manufacturer supplies with a Product is limited to use only to validate the relevant Product. By using the Product, Customers agree not to attempt to reverse engineer or otherwise perform any compositional, structural, functional or other analyses directed to learning the methodology, formulae, sequences, processes, make-up or production of any of the Products or portions thereof.