Anti-CD5 Mouse Monoclonal Antibody [clone: UCHT2] (Biotin)

Catalog # STMC60082BT

Supplier: STEMCELL Technologies

Catalog # STMC60082BT

Supplier: STEMCELL Technologies

Specifications

Nom de l'antigène:
CD5
Clonalité:
Monoclonal
Clone:
UCHT2
Conjugaison:
Biotin
Hôte:
Mouse
Isotype:
IgG1 kappa
Réactivité:
Capuchin monkey,
Cynomolgus monkey,
Common marmoset,
Rhesus monkey,
Chimpanzee,
Human,
Owl monkey
ID de gène:
921
Cdt:
100 µG

Specifications

About this item

Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD5, biotin-conjugated.

T cells

The UCHT2 antibody reacts with CD5, an ~67 kDa single-chain type I glycoprotein and member of the scavenger receptor superfamily, which is constitutively expressed on thymocytes, T cells, B cell subsets, peripheral blood dendritic cells and some leukemia and lymphoma cells, including chronic B lymphocytic leukemia (B-CLL) cells. CD5 is expressed at low levels on thymocytes and at high density on mature T cells. Putative ligands include CD5L and CD72. CD5 modulates T and B cell receptor signaling, thymocyte maturation, and T cell/B cell interactions via its physical and functional associations with the T cell receptor/CD3 complex and the B cell receptor. Studies with CD5 knockout mice indicate that CD5 negatively regulates antigen receptor-mediated signaling in thymocytes and mature T cells. The UCHT2 antibody binds to epitope 2 located in the extracellular domain of CD5.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD5
Clonality: Monoclonal
Clone: UCHT2
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Capuchin monkey;Chimpanzee;Common marmoset;Cynomolgus monkey;Human;Owl monkey;Rhesus monkey