Anti-IL-4 Rat Monoclonal Antibody [clone: MP4-25D2]

STMC100-1454

: STEMCELL Technologies

Anti-IL-4 Rat Monoclonal Antibody [clone: MP4-25D2]

STMC100-1454

: STEMCELL Technologies

Nom de l'antigène:
IL-4
Clonalité:
Monoclonal
Clone:
MP4-25D2
Hôte:
Rat
Isotype:
IgG1 kappa
Réactivité:
Human
ID de gène:
3565
Cdt:
100 µG

Rat monoclonal antibody against human IL-4, unconjugated.

T cells CD4

This rat monoclonal antibody (clone MP4-25D2) reacts with human interleukin 4 (IL-4). IL-4 is an ~15 kDa protein primarily composed of a four-helix bundle (Powers et al.) and is produced by a host of immune cells including T helper 2 (Th2) cells, basophils, eosinophils, and mast cells (Gadani et al.). It exhibits high affinity for the IL-4 receptor alpha (IL-4Rα) chain, which dimerizes with either the common gamma chain (γc) or IL-13 receptor alpha 1 (IL-13Rα1), leading to activation of downstream JAK-STAT signaling (Heller at al.). IL-4 is involved in the differentiation of CD4+ T lymphocytes into Th2 cells (Silva-Filho et al.), class switching of B cells to IgE (Geha et al.), and activation of M2 macrophages with IL-13 via an alternative pathway (Gordon et al.).

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Type: Anti-IL-4 Rat Monoclonal Antibody [clone: MP4-25D2]
Antigen: IL-4
Clonality: Monoclonal
Clone: MP4-25D2
Conjugation: Unconjugated
Epitope:
Host: Rat
Isotype: IgG1 kappa
Reactivity: Human