Mouse monoclonal IgG1 antibody against human, rhesus, cynomolgus CD2, APC-conjugated.

• T cells

The RPA-2.10 antibody reacts with CD2, an ~50 kDa type I transmembrane glycoprotein and a member of the immunoglobulin (Ig) superfamily; two Ig-like domains are located in its extracellular portion. CD2 is broadly expressed on peripheral T and NK cells, dendritic cells, erythrocytes, most thymic T cells, subsets of thymic B cells, and on the endothelium. CD2 expression appears early during T cell differentiation. Aberrant expression has been observed in some lymphomas and myeloid leukemias. CD2 is critically important for T cell activation and signaling, as well as lymphocyte adhesion. The primary ligand for CD2 is CD58 (LFA-3) located on antigen-presenting cells, with additional ligands comprising CD15 (SSEA-1), CD48 and CD59. Notably, the RPA-2.10 antibody blocks the mixed lymphocyte reaction.

Type: Anti-CD2 Mouse Monoclonal Antibody [clone: RPA-2.10] (APC)
Antigen: CD2
Clonality: Monoclonal
Clone: RPA-2.10
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Baboon, Capuchin monkey, Chimpanzee, Cynomolgus monkey, Human, Pig, Pigtailed macaque, Rhesus monkey, Squirrel monkey