CMV (UL44) Peptide Pool

Stimulating T cells with CMV (UL44) peptide pool releases downstream cytokines and upregulates activation markers, enabling antigen-specific T cells to be detected or isolated for analysis. CMV (UL44) peptide pool is a lyophilised mixture of 106 peptides from DNA polymerase processivity factor UL44 of human cytomegalovirus (CMV; strain AD169), and consists of 15-mer peptides with 11-amino-acid overlaps that cover amino acids 1 to 433 on UL44. UL44 contains a nuclear localization signal (Alvisi et al.) and may bind DNA directly, or form a C clamp partially surrounding it, similar to proliferation cell nuclear antigen (PCNA) (Appleton et al.). UL44 has also been found to interact with viral (Kim and Ahn) and host (Strang et al.) proteins that contribute to viral DNA replication and efficient viral growth. Viral peptide pools are useful for a broad range of applications, including vaccine development, immunological research, and diagnostic assay development.

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