Specifications
- Type d'anticorps:Primaire
- Nom de l'antigène:APLF
- Clonalité:Polyclonal
- Conjugaison:Alexa Fluor® 680
- Hôte:Rabbit
- ImmunoChimie:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Réactivité:
- Western blot:Yes
- Environmentally Preferable:
- Épitope:421-511/511
- Formulaire:Liquid
- ID de gène:200558
- Synonymes antigène:XIP1|APLF_HUMAN|Apurinic-apyrimidinic endonuclease APLF|AI452191|PNK and APTX like FHA protein|Aprataxin and pnk-like factor|Aplf|XRCC1 interacting protein 1|2010301N04Rik|PNK and APTX-like FHA domain-containing protein|XRCC1-interacting protein 1|RGD1565557|C2orf13
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:57 kDa
- Température de stockage:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Température de transport:4 °C
- Immunogène:KLH conjugated synthetic peptide derived from human APLF
- Tested applications:ICC
- Purification:Purified by Protein A
- Type de conditionnement:Vial
- Cdt:100 µl
Specifications
About this item
APLF is a 511 amino acid protein that contains one FHA domaIn and two C2H2type zinc fingers. localised to both the nucleus and the cytoplasm, APLF interacts with XRCC1, XRCC4 and Ku-86 and, via these interactions, is involved in single-strand and double-strand DNA break repair. APLF is subject to post-translational phosphorylation in response to DNA breaks. The gene encoding APLF maps to human chromosome 2, which houses over 1400 genes and comprises nearly 8% of the human genome. Harlequin icthyosis, a rare and morbid skin deformity, is associated with mutations in the ABCA12 gene, while the lipid metabolic disorder sitosterolemia is associated with defects in the ABCG5 and ABCG8 genes. Additionally, an extremely rare recessive genetic disorder, is caused by mutations in the ALMS1 gene, which maps to chromosome 2.
Type: Primary
Antigen: APLF
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 421-511/511
Host: Rabbit
Isotype: IgG
Reactivity: