Spécifications
- Type d'anticorps:Primaire
- Nom de l'antigène:ASK1 Ser967
- Clonalité:Polyclonal
- Conjugaison:Alexa Fluor® 680
- Hôte:Rabbit
- ImmunoChimie:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Réactivité:Human,Rat,Mouse
- Western blot:Yes
- Environmentally Preferable:
- Formulaire:Liquid
- ID de gène:4217
- Synonymes antigène:MEK kinase 5|MEKK 5|MEKK5|ASK-1|Mitogen-activated protein kinase kinase kinase 5|MAPK/ERK kinase kinase 5|MAP3K5|MAPKKK5|Apoptosis signal-regulating kinase 1|M3K5_HUMAN|ASK1
- Modification:Phosphorylation (Ser967)
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:155 kDa
- Température de stockage:Store at −20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Température de transport:4 °C
- Immunogène:KLH conjugated synthetic phosphopeptide derived from human ASK1 around the phosphorylation site of Ser967
- Tested applications:ICC
- Purification:Purified by Protein A
- Type de conditionnement:Vial
- Cdt:100 µl
Spécifications
À propos de cet article
Mitogen-activated protein kinase (MAPK) signaling cascades include MAPK or extracellular signal-regulated kinase (ERK), MAPK kinase (MKK or MEK), and MAPK kinase kinase (MAPKKK or MEKK). MAPKK kinase/MEKK phosphorylates and activates its downstream protein kinase, MAPK kinase/MEK, which in turn activates MAPK. The kinases of these signaling cascades are highly conserved, and homologs exist in yeast, Drosophila, and mammalian cells. MAPKKK5 contains 1,374 amino acids with all 11 kinase subdomains. Northern blot analysis shows that MAPKKK5 transcript is abundantly expressed in human heart and pancreas. The MAPKKK5 protein phosphorylates and activates MKK4 (aliases SERK1, MAPKK4) in vitro, and activates c-Jun N-terminal kinase (JNK)/stress-activated protein kinase (SAPK) during transient expression in COS and 293 cells; MAPKKK5 does not activate MAPK/ERK.
Type: Primary
Antigen: ASK1 Ser967
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range:
Host: Rabbit
Isotype: IgG
Reactivity: Human; Mouse; Rat