Specifications
- Type d'anticorps:Primaire
- Nom de l'antigène:Dachshund Family Transcription Factor 1
- Symbole de l'antigène:DACH1
- Clonalité:Polyclonal
- Conjugaison:Unconjugated
- ELISA:Yes
- Hôte:Rabbit
- ImmunoChimie:Yes
- Précipitation immunologique:Yes
- Isotype:IgG
- Réactivité:Human,Rat,Mouse
- Western blot:Yes
- ChIP:Yes
- Synonymes antigène:DACH|FLJ10138|dachshund homolog 1 (Drosophila) |DACH1|dachshund homolog 1|RP11-512J14.1
- Storage buffer:PBS with 0,1% sodium azide and 50% glycerol pH 7,3
- Température de transport:Store at ‒20 °C
- Immunogène:Recombinant Protein
- Purification:Antigen affinity Purification
- Cdt:1
Specifications
About this item
DACH1, a homologue of the Drosophila dachshund gene, is a key regulator of cell fate determination during eye, leg, and brain development in the fly. Through interacting with NCoR and Smad4, DACH1 is able to inhibit the transforming growth factor-beta (TGF-beta) signaling pathway. DACH1 can inhibit breast cancer cellular proliferation via cyclin D1, suggesting a possible role in tumor suppression. Additionally, DACH1 plays an important role in negative regulation of RANKL (Receptor activator of NF-kappaB ligand ) gene expression in marrow stromal/preosteoblast cells, and loss of DACH1 expression might be involved in endometrial cancer progression. Four isoforms of DACH1 are produced by alternative splicing. This antibody is a rabbit polyclonal antibody raised against residues near the C terminus of human DACH1.
Western Blot: MCF7 Cells, 1:500 to 1:5000; IHC: Human Prostate Cancer Tissue, 1:20 to 1:200; IP: HEK to 293 Cells, 1:500 to 1:5000
Type: Primary
Antigen: DACH1
Clonality: Polyclonal
Clone:
Conjugation: Unconjugated
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat