Inhibitor of PP1 and PP2A

Analog of microcystin-LR (Prod. No. ALX-350-012) with Tyr substituted in place of Leu. As for all microcystins the conjugated double bonds in the ADDA moiety cause a characteristic absorption maximum at 238 nm. The Tyr residue in position 2 of microcystin-YR confers an absorption maximum at 232 nm. Potent inhibitor of eukaryotic protein phosphatases 1 and 2 A. Useful as a reference compound in environmental analysis. The hydroxyl group of the Tyr residue may prove useful for linking microcystin-YR via conjugation to other chemicals. Inhibits the synthesis of proteases such as cathepsin D and L, and arginine aminopeptidase.

Isolated from Microcystis aeruginosa.