Pierce™ Protein A and Protein G Spin Plates for IgG Screening offers a high throughput format for quick purification and screening of antibodies and for immunoprecipitation (IP). Each well of the 96-well spin plate can process 10 to 100 µl of serum, cell culture supernatant or ascites fluid samples.

The Protein A and Protein G resin purifies by binding IgGs, primarily through their Fc region, in a buffer that facilitates the interaction. Non-relevant proteins, such as albumin and transferrin, are removed by washing and the purified antibody is then recovered using low-pH elution conditions.