Capto™ adhere ImpRes is a strong anion exchange multimodal BioProcess chromatography medium (resin), designed to meet the demands of modern large-scale manufacturers, for high-resolution polishing of monoclonal antibodies (MAbs) and other biomolecules. Capto™ adhere ImpRes is designed to allow effective MAb polishing in the second or third step of a purification scheme downstream of the protein A capture step. Polishing can be performed in either bind and elute (binding) or flowthrough (non binding) modes.

• High yields achieved through the high-resolution beads and selectivity of the ligand
• Efficient removal of aggregates, viruses, and main contaminants in MAb processes
• Enables use of a platform approach to MAb process development
• Allows separation of MAb charged variants

The high selectivity of the anion multimodal ligand allows operation in a variety of process conditions to solve challenging purification problems. Contaminants such as DNA, host cell proteins, leached protein A, aggregates, and viruses are efficiently removed. The multimodal anion exchanger ligand of Capto adhere ImpRes is immobilized to the base matrix and interacts with the target molecule through multiple types of interactions. Capto adhere ImpRes is available in a range of different bulk pack sizes for easy scale-up and pre-packed formats for process development. As member of the BioProcess media range, Capto adhere ImpRes meets industrial demands with security of supply and comprehensive technical and regulatory support.