12531 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Immunoglobulin G (IgG) is an immunoglobulin monomer consisting of two (gamma) heavy chains and two light chains. Each IgG molecule contains two antigen binding domains and a single effector (Fc) domain. Assay Designs offers isotyping kits and antibodies in a variety of formats for the detection of human, mouse, rabbit, rat, sheep, and goat IgG.

Supplier: Enzo Life Sciences

Broad-spectrum kinase inhibitor

Supplier: Enzo Life Sciences

HDAC inhibitor

Supplier: Enzo Life Sciences

Glyceraldehyde 3-phosphate dehydrogenase (GAPDH) is responsible for one of the steps in the glycolytic pathway. GAPDH is essential for cellular metabolism.

Supplier: Enzo Life Sciences

TAP1 and TAP2 are two structurally related subunits of the Transporter associated with antigen processing (TAP). The TAP complex is a member of the ATP binding cassette (ABC) family of transmembrane transporters. The TAP transporter is an essential component of the MHC class I antigen presentation pathway by binding peptides in its cytosolic part and subsequently translocating the peptides into the lumen of the endoplasmic reticulum where assembly of MHC class I and pepide takes place.

Supplier: Enzo Life Sciences

Potent, selective inhibitor of iNOS (NOS II). The Ki values for inhibition of iNOS (NOS II), nNOS (NOS I), and eNOS (NOS III) by ENIPO are 17, 10.3 and 58.2 µm, respectively, as determined using initial rate binding kinetics. However, ENIPO is a time-dependent inhibitor that, with longer incubations, demonstrates reversible tight binding inhibition that is selective for iNOS (NOS II) over nNOS (NOS I) or eNOS (NOS III). This selectivity results from iNOS (NOS II) exhibiting a 4-fold faster binding and 10-fold slower dissociation with ENIPO compared to nNOS (NOS I). Ki values for ENIPO binding to iNOS (NOS II) and nNOS (NOS I) are 0.56 and 6 µm, respectively. Accurate determination of the Ki value of ENIPO for eNOS (NOS III) has not been determined but is expected to be 50-fold less than iNOS (NOS II).

Supplier: Enzo Life Sciences

Nicotinic acetylcholine receptor activator.

Supplier: Enzo Life Sciences

Human DNA fragmentation fragment (DFF) 45 and its mouse homologue caspase activated deoxyribonuclease (ICAD) are the inhibitors of DFF40 and CAD, respectively.

Supplier: Enzo Life Sciences

The 17β-Estradiol (Serum/Plasma) EIA kit is a colorimetric competitive enzyme immunoassay kit with results in 3 hours.

Supplier: Enzo Life Sciences

TLR4 activator.

Supplier: Enzo Life Sciences

CDK inhibitor

Supplier: Enzo Life Sciences

The TLRs (Toll-like receptors) are a group of evolutionarily conserved pattern recognition molecules that play a key role in host defense during microbial infection by regulating both innate and adaptive immune responses. TLRs are type I transmembrane proteins with ectodomains containing interspersed leucine-rich repeat (LRR) motifs that are involved in the recognition of various microbial ligands. Detects a band of ~90kDa by Western blot.

Supplier: Enzo Life Sciences

HIF-1α activator.

Supplier: Enzo Life Sciences

A SIRT1 activator.

Supplier: Enzo Life Sciences

Methyltransferase inhibitor

Supplier: Enzo Life Sciences

Potent stimulator of NKT cells.

Supplier: Enzo Life Sciences

Topoisomerase inhibitor

Supplier: Enzo Life Sciences

Inhibitor of PP1 and PP2A

Supplier: Enzo Life Sciences

Endogenous cannabinoid. Weak ligand of CB1 (Ki=23.8µM) and CB2 (Ki=13.9µM) receptor. Inhibits fatty acid amide hydrolase (FAAH) (IC50=5.1µM). Immunosuppressant, anti-inflammatory, anti-nociceptive and anti-convulsant in vivo. The exact mode of action has not yet been revealed. It has been suggested that PEA: i) binds to a yet to be discovered cannabinoid receptor similar to CB2; ii) administered in vivo elicits the synthesis of endogenous agonists of CB2; iii) acts as an "entourage" compound by enhancing the activity and/or by influencing the turnover of endogenous agonists of CB2, possibly but not uniquely, by inhibiting their degradation.

Supplier: Enzo Life Sciences

Cell permeable modulator of actin-related protein 3 (Arp3). Inserts into the hydrophobic core of Arp3 and alters its conformation. Inhibits human and Bos taurus Arp2/3 complex, actin polymerization (IC50=11µM) and the formation of podosomes.Inhibits polymerization (IC50=31µM), stimulated by ActA, a comet tail formation inducer from Listeria monocytogenes.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

DMOG is a cell permeable prolyl-4-hydroxylase inhibitor which upregulates HIF activity. HIF activation stimulates angiogenesis in several different models. DMOG also inhibits FIH (Factor Inhibiting HIF), an asparaginyl hydroxylase, which enhances the HIF response. It is active in vivo and attenuates myocardial injury in a rabbit ischemia reperfusion model (20mg/kg). Is expected to act pro-angiogenic.

Supplier: Enzo Life Sciences

A novel geldanamycin fluorescent probe that may be used in a fluorescence polarization assay for HSP90 inhibitors. May also be used for detection of cell surface HSP90.

Supplier: Enzo Life Sciences

PD-98059 is a potent and selective inhibitor of MAP kinase kinase (MEK). It selectively blocks the activation of MEK thereby inhibiting the phosphorylation and the activation of MAP kinase. PD-98059 is cell permeable. In PC12 pheochromocytoma cells, it completely blocked the increase in MAP kinase activity produced by NGF, IC50=2µM. Enhances self-renewal of embryonic stem cells PD-98059 is an invaluable tool to help elucidate the role of the MAPK cascade in a variety of biological systems. Inhibits cell growth and proliferation in acute myelogenous leukemia cell lines by causing cell arrest.

Supplier: Enzo Life Sciences

Highly active

Supplier: Enzo Life Sciences

Produced in insect cells. Active FAK (aa 411-686).

Supplier: Enzo Life Sciences

PTP1B inhibitor

Supplier: Enzo Life Sciences

Organic vanadium complex which acts as a potent insulin mimic.

Supplier: Enzo Life Sciences

Serotonin transporter inhibitor

Supplier: Enzo Life Sciences

PTP1B inhibitor