5140 Results for: "Enzo Life Sciences"

Amine-reactive quencher dye has a broad visible absorption but no detectable fluorescence emission in fluorescence resonance energy transfer (FRET) applications.

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Rat recombinant HSP60 (from E. coli)

Supplier: Enzo Life Sciences

Produced in E. coli.

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(-)-Arctiin (from Arctium lappa) ≥95% (by HPLC)

Supplier: Enzo Life Sciences

Lignan derivative with antitumor activities. Down-regulates anti-apoptotic protein Bcl-XL. Potent inhibitor of HIV type-I integrase and DNA topoisomerase II. Shows phytoestrogenic activity and is an antagonist for platelet activating factor and Ca²⁺.

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Streptozocin ≥97%

Supplier: Enzo Life Sciences

Widely used diabetes inducer in rodents. Inhibition of β-cell O-GlcNAcase by streptozotocin is the mechanism that accounts for its diabetogenic toxicity. N-nitroso-containing antibiotic, acting as a nitric oxide (NO) donor and vasorelaxant. Relaxes phenylephrine-contracted aortic rings at 10µM. Potent methylating agent for DNA.

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Anti-FKBP59 Mouse Monoclonal Antibody [clone: KN382/EC1]

Supplier: Enzo Life Sciences

FKBP59, also known as Hsp56/p59 is an immunophilin that is a component of Hsp70/Hsp90/steroid receptor complexes. Expression of FKBP59 is increased in response to heat shock and ischemic stress, and is thought to play a role in the folding and cytoplasmic/nuclear distribution of steroid receptors.

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Anti-SYT Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Synaptotagmins (Syt) are membrane-trafficking proteins characterized by an N-terminal transmembrane region, a variable linker, and two C-terminal C2-domains, C2A and C2B. At least twelve Synaptotagamins are expressed in vertebrates and can be found in both vesicular and plasma membranes.

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IHC universal negative control reagent

Supplier: Enzo Life Sciences

IHC universal negative control reagent is specifically designed to work with rabbit, mouse and goat antibodies.

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Furin convertase Substrate (fluorogenic)

Supplier: Enzo Life Sciences

Fluorogenic substrate for furin/SPC1/PACE/PCSK3 and other subtilisin/kexin-like proprotein convertases such as Kex2, SPC2/PC2/PCSK2, SPC3/PCSK1, PACE4/SPC4/PCSK6, SPC5/PC4/PCSK4, SPC6/PC5/PC6/PCSK5, and SPC7/LPC/PC7/PC8/PCSK7. Can be used on live cells. Ex: 340-360 nm, Em: 440-460 nm.

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Ac-YVAD-CMK

Supplier: Enzo Life Sciences

Inhibitor of caspase-1 and -4

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Z-DEVD-pNA

Supplier: Enzo Life Sciences

Caspase substrate

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Anti-CASP9 Rabbit Polyclonal Antibody

Supplier: Enzo Life Sciences

The caspases are a family of cysteine proteases that cleave after certain aspartate residues, and are primarily recognized as mediators of apoptosis. caspases are synthesized as inactive zymogens that can be cleaved to form active enzymes following the induction of apoptosis by stress or death receptors. Initiator caspases (e.g. caspase-8 and -10) are activated by dimerization of the zymogen on a dedicated adaptor protein. These activated initiator caspases in-turn cleave downstream effector or executioner caspases (e.g. caspase-3, -6, and -7) in a cascade-like manner, which cleave key cellular proteins that lead to the morphological changes associated with apoptotic cell death.

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Ac-YVAD-AFC

Supplier: Enzo Life Sciences

Substrate for caspase-1 and -4

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SB203580 ≥97%

Supplier: Enzo Life Sciences

Protein kinase inhibitor

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beta-Amyloid (1-40)

Supplier: Enzo Life Sciences

beta-Amyloid (1-40)

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L-Thiocitrulline dihydrochloride ≥97%

Supplier: Enzo Life Sciences

NOS inhibitor

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Wnt pathway library, Screen-Well®

Supplier: Enzo Life Sciences

The Screen-Well® Wnt pathway library v 2.0 is a focused collection of 71 compounds with defined and diverse Wnt pathway activity, including activators and inhibitors of Wnts, Dishevelled, GSK-3β and other Wnt pathway kinases, TCF/β-catenin, DKK, LRP, Axin, Porcupine, and more. Compounds are dissolved in DMSO at 10 mM or 1 mM and aliquoted into deep-well plates at 100 or 500 µl per well. A variety of structurally and mechanistically different compound classes are included. A useful tool for studying the roles of pro- and anti-Wnt pathway molecules in cells as well as for use in in vitro applications.

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ETB receptor antagonist . sodium salt

Supplier: Enzo Life Sciences

Highly potent and selective ETB-receptor antagonist.

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Mouse recombinant GITR:Fc

Supplier: Enzo Life Sciences

Produced in HEK 293 cells. The cysteine-rich region of mouse GITR (aa 20-152) is fused to the Fc portion of human IgG1.

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Anti-Glutathione Mouse Monoclonal Antibody

Supplier: Enzo Life Sciences

Glutathione, a major intracellular non-protein thiol, protects against free radical damage by providing reducing equivalents for several key antioxidant enzymes. In addition, glutathione acts as a scavenger of hydroxyl radicals and nascent oxygen. Elevated glutathione levels are associated with a reduced rate of illness, higher levels of self-rated health, lower cholesterol, lower body mass index, and lower blood pressure among the elderly. Glutathione provides a primary defense system for the removal of oxidants in the brain. Studies have revealed a correlation between low glutathione levels and damage to neurons that manufacture dopamine, suggesting a link to Parkinson's disease.

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Matrix Metalloproteinase-7 (MMP-7) fluorometric drug discovery kit

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-7 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-7 (MMP-7, matrilysin) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties.