5140 Results for: "Enzo Life Sciences"

Supplier: Enzo Life Sciences

Prostanoid receptor ligand.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli. C-terminal Human caspase-9 (aa 131-416).

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Microcystins are a group of cyclic heptapeptide hepatotoxins produced by a number of cyanobacterial genera. The most notable of which, and namesake, is the widespread genus Microcystis. Structurally, all microcystins consist of the generalized structure cyclo(-D-Ala1-X2-D-MeAsp3-Y4-Adda5-D-Glu6-Mdha7-). X and Y are variable L-amino acids, D-MeAsp is D-erythro-β-methylaspartic acid and Mdha is N-methyldehydroalanine. Adda is the cyanobacteria unique C20 β-amino acid 3-amino-9-methoxy-2,6,8-trimethyl-10-phenyl-deca-4,6-dienoic acid. Substitutions of the variable L-amino acids at positions 2 and 4 give rise to at least 21 known primary microcystin analogs and alterations in the other constituent amino acids result in more than 90 reported mycrocystins to date.

Supplier: Enzo Life Sciences

Tyrosine kinase inhibitor

Supplier: Enzo Life Sciences

DGAT inhibitor

Supplier: Enzo Life Sciences

Inhibitor of caspase-1, -4 and -5

Supplier: Enzo Life Sciences

Inhibits PKA (Ki=3.0μM), PKG (Ki=5.8μM), MLCK (Ki=97μM) and PKC (Ki=6μM). Also inhibits myosin light chain kinase. Induces apoptotic DNA fragmentation and cell death. Inhibits telomerase activity in treated NPC-076 cells. Cell permeable.

Supplier: Enzo Life Sciences

DNA-topoisomerase II, also known as Topo II or Top 2, is a multifunctional nuclear enzyme required during DNA replication, chromosome disjunction at mitosis, and other DNA-related activities because of its ability to alter DNA supercoiling. In mammalian cells, Topo II consists of two isozymes, Topo II-alpha (170kDa) and Topo II-beta (180kDa) and expression and localization of each isoform are distinct and stage specific during the cell cycle. Topo II-beta is expressed constitutively throughout the cell cycle, whereas the expression of Topo II-alpha is cell cycle-regulated, peaking in G2 to M phase and declining to a minimal level at the end of M phase. DNA-topoisomerase II is the target of some of the most active drugs used in chemotherapy and has been shown to have a critical role in neural development.

Supplier: Enzo Life Sciences

SCREEN-WELL® bioactive lipid library contains 190 bioactive lipids in a 96 well format. Ideal for screening or identifiying recombinant orphan G protein-coupled receptors, target validation, secondary screening, validating new assays and for routine pharmacological applications.

Supplier: Enzo Life Sciences

Angiotensin I

Supplier: Enzo Life Sciences

The Screen-Well® epigenetics library contains 43 compounds with defined activity against enzymes which carry out epigenetic modification of lysine. It also includes DNA methylation inhibitors. Compounds are dissolved in DMSO at 10 mM and aliquoted into deep-well plates at 100 µl or 500 µl per well. The library is a useful tool for chemical genomics, assay development and other pharmacological applications. The library contains inhibitors of these important enzymes: HDACs, SIRTs, Lysine demethylases, HATs, Histone methyl transferases, DNA methyltransferases as well as SIRT activators. A variety of structurally and mechanistically different compound classes are included.

Supplier: Enzo Life Sciences

beta-Amyloid (25-35)

Supplier: Enzo Life Sciences

Antibiotic. Inhibits protein synthesis (elongation) by interfering with peptidyl tRNA translocation. Effective against Gram-negative and Gram-positive bacteria (Gonnococcus only). Mutation in rpsE (the gene for ribosomal protein S5) prevents binding of spectinomycin.

Supplier: Enzo Life Sciences

Hsp47, also known as colligin and gp46, is an ER-resident collagen-specific stress glycoprotein involved in the synthesis and assembly of varoius collagens as a molecular chaperone.

Supplier: Enzo Life Sciences

Anacardic acid ≥95% (by 1H-NMR)

Supplier: Enzo Life Sciences

Calreticulin (CRT) is a multifunctional, multi-compartmental protein most abundant in the ER lumen. CRT contains the ER-retrieval sequence, KDEL, and has been best characterized as a soluble molecular chaperone of new or misfolded proteins and a Ca2+- binding protein. Both CRT and its membrane bound homolog, Calnexin (CNX) interact with proteins and glycoproteins that have monoglucosylated N-glycans. The CRT/CNX cycle promotes correct folding, inhibits aggregation of folding intermediates, blocks premature oligimerization, regulates ER degradation, and provides quality control by preventing incompletely folded glycoproteins from exiting to the Golgi complex.

Supplier: Enzo Life Sciences

Selective inhibitor of JAK1 and JAK2 kinases including the JAK2 V617F mutant

Supplier: Enzo Life Sciences

Smoothened ligand

Supplier: Enzo Life Sciences

Capsaicin antagonist

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-10 Fluorometric (also known as fluorimetric) Drug Discovery Kit is a complete assay sytem designed to screen for inhibitors of matrix metalloproteinase-10 (MMP-10, stromelysin-2) using a quenched fluorogenic peptide: OmniMMP™ fluorogenic substrate Mca-Pro-Leu-Gly-Leu-Dpa-Ala-Arg-NH. Mca fluorescence is quenched by the Dpa group until cleavage by MMPs at the Gly-Leu bond separates the two moieties.

Supplier: Enzo Life Sciences

Antitumor agent.

Supplier: Enzo Life Sciences

Inducer of intracellular ROS generation.

Supplier: Enzo Life Sciences

Highly sensitive ELISA kit for the detection of Arg8-Vasopressin in serum, plasma and tissue culture media.

Supplier: Enzo Life Sciences

Produced in insect cells. Full length active enzyme.

Supplier: Enzo Life Sciences

Produced in E. coli. Human 14-3-3gamma is fused at the C-terminus to a His-tag.

Supplier: Enzo Life Sciences

Ultra-pure; stabilizes microtubules

Supplier: Enzo Life Sciences

Cell-permeable inhibitor of VEGF receptors, PDGFR, and Kit receptor.