12531 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

Recommended Applications: Flow Cytometry

Species reactivity: Human, Mouse, Dog

Supplier: Enzo Life Sciences

Toll-like receptors (TLRs) are one of the mechanisms by which the innate immune system senses the invasion of pathogenic microorganisms. TLRs are primary transmembrane proteins of immune cells; they have an extracellular region which contains leucine-rich repeat motifs, and a cytoplasmic tail, which has a Toll/interleukin-1 (IL-1) receptor (TIR) domain. TLRs are pattern recognition receptors (PRRs ) that bind to pathogen-associated molecular patterns (PAMPs). Different TLRs recognize different surface and intracellular components of microorganisms or PAMPS. The interaction between a TLR and a microbial component or PAMP triggers the activation of the innate immune system, as well as the development of acquired immunity. Interaction of PAMPs with different TLRs induces distinct patters of gene expression through signal transduction pathways. TLR signaling occurs through the TIR domains which utilize adaptors such as MyD88, TIRAP, TRIF, and TRAM. NF-kappa-B and JNK pathways are activated leading to the transcription of genes encoding pro-inflammatory cytokines. TLR-10, originally identified from a spleen cDNA library, is on chromosome 4p14 and has been found to be expressed in lung and in B-lymphocytes. TLR10 is thought to be a potential asthma candidate gene because early life innate immune responses to ubiquitous inhaled allergens and PAMPs may influence asthma susceptibility.

Supplier: Enzo Life Sciences

Recommended Applications: ICC, IHC, IP, WB

Species reactivity: Species independent

Supplier: Enzo Life Sciences

Mycotoxin found in cereals. Binds to the ribosome and inhibits protein synthesis.
Emetic and refusal activity in pig.

Supplier: Enzo Life Sciences

The Ha-Tag (YPYDVPDYA) corresponds to the partial peptide sequence of the influenza hemagglutinin protein. Recognizes the HA-tag of HA-tagged recombinant proteins.

Supplier: Enzo Life Sciences

APP695 is the most predominant form in neuronal tissue while APP751 is the predominant form found elsewhere. There are five forms of APP: APP395, APP563, APP695, APP751, and APP770.

Supplier: Enzo Life Sciences

Gc-globulin is a 50kDa plasma protein produced in the liver, with a concentration in human plasma of approximately 400 µg/mL. Because vitamin D is amongst its ligands, Gc-globulin is also known as vitamin D-binding protein. Gc-globulin is also part of the actin scavenging system, binding and removing monomeric actin from the blood stream.

Supplier: Enzo Life Sciences

Mouse neutrophil gelatinase-associated lipocalin (NGAL; also lipocalin 2, 24p3, SIP24, uterocalin and siderocalin) belongs to the lipocalin family of proteins which bind and transport small lipophilic molecules. Following research showing 24p3 dramatically upregulated in kidney cell cultures infected with SV40, it was subsequently identified as a lipocalin. Unlike human NGAL, mouse NGAL is an acute phase protein upregulated in the liver, but like its mammalian homologues, it is upregulated and secreted by the kidney in response to ischemic or nephrotoxic injury. It is also upregulated in the involuting uterus and mammary gland.

Supplier: Enzo Life Sciences

BCMA (B cell maturation) is a nonglycosylated integral membrane type I protein that is preferentially expressed in mature B lymphocytes and belongs structurally to the TNF receptor family. BCMA associates with BAFF, APRIL, TNF receptor-associated factor (TRAF) 1, TRAF2, and TRAF3 and activates NF-κB, Elk-1, c-Jun N-terminal kinase (JNK), and p38 mitogen-activated protein kinase. BCMA plays an important role in B cell development, function and regulation.

Supplier: Enzo Life Sciences

LRRC32 (leucine rich repeat containing 32; also known as GARP or Garpin; Glycoprotein A repetitions predominant) is a glycoprotein expressed on the cell surface of megakaryocytes, platelets and activated regulatory T (Treg) cells.

Supplier: Enzo Life Sciences

Produced in insect cells. Full length active PLK1 is fused at the N-terminus to a His-tag.

Supplier: Enzo Life Sciences

Sequence is histone H2B (29-35) non-phosphorylatable analog (Ser to Ala32) of substrate peptide of PKG. Ki =86 µM for PKG; Ki =550 µM for PKA.

Supplier: Enzo Life Sciences

This peptide sequence, EFpYAEVGRSPPDPAK, was selected by phage display analysis for optimal Shp-1 and Shp-2 phosphatase activities.

Supplier: Enzo Life Sciences

Highly potent and selective serotonin uptake inhibitor

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Selective agonist of TLR1/TLR2 complex

Supplier: Enzo Life Sciences

Food intake modulator

Supplier: Enzo Life Sciences

PPARgamma antagonist

Supplier: Enzo Life Sciences

Phomopsin A ≥98% (by HPLC)

Supplier: Enzo Life Sciences

Recombinant human matriptase (aa 596-855) fused at the N-terminus to a His-tag.

Supplier: Enzo Life Sciences

Dual 5-lipoxygenase (IC50=46.8 µM) and cyclooxygenase I and II inhibitor (IC50=0.6 µM). Clinically useful NSAID.

Supplier: Enzo Life Sciences

Produced in Sf21 cells. Human full-length PARP-3 is fused to a His-tag.

Supplier: Enzo Life Sciences

Produced in E.coli and fused to a His-tag.

Supplier: Enzo Life Sciences

Produced in E. coli. alpha-synuclein is a major component of Parkinson's disease aggregates and is implicated in the pathogenesis of Parkinson's disease and related neurodegenerative disorders.

Supplier: Enzo Life Sciences

Water soluble form of aristolochic acid.

Supplier: Enzo Life Sciences

Produced in E. coli. Homologous to human serum leptin.

Supplier: Enzo Life Sciences

Produced in E. coli. Fused at the N-terminus to a His-tag.

Supplier: Enzo Life Sciences

Produced in E. coli.

Supplier: Enzo Life Sciences

Produced in E. coli. Human eIF2α is fused at the N-terminus to a His-tag.