12530 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG2b

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgM

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide.

Supplier: Enzo Life Sciences

PTP1B inhibitor

Supplier: Enzo Life Sciences

From cytomegalovirus, strain AD169. Inactivated by 0.2% Triton X-100.

Supplier: Enzo Life Sciences

From herpes simplex virus type 2, strain G. Inactivated by 0,1% Triton X-100.

Supplier: Enzo Life Sciences

Biosynthesis via 15-OH prostaglandin dehydrogenase from lung and liver microsomes and by a nonenzymatic process.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Biosynthesis from dihomo-γ-linolenic acid.

Supplier: Enzo Life Sciences

2,3-Dinor-6-ketoprostaglandin F1α-20,20,20-d3 ≥98% (by TLC), Ultrapure

Supplier: Enzo Life Sciences

Produced in E.coli. Active Matrix Metalloproteinase-14 (MMP-14, Membrane-Type Matrix Metalloproteinase 1, MT1-MMP) catalytic domain from human cDNA.

Supplier: Enzo Life Sciences

Produced in E. coli. Contains a N-terminal His-tag.

Supplier: Enzo Life Sciences

High purity industry standard substrate for deubiquitinylating enzymes (DUBs).

Supplier: Enzo Life Sciences

Produced in yeast. Recombinant human granzyme B (aa 21-247).

Supplier: Enzo Life Sciences

Widely used PKC activator (10 to 100 ng/ml).

Supplier: Enzo Life Sciences

ATPase inhibitor

Supplier: Enzo Life Sciences

PAR-4 belongs to a four member family of G protein-coupled receptors (PAR-1 to -4) that are activated as a result of proteolytic cleavage by certain serine proteases, hence their name. In this modality of activation, a specific proteinase cleaves the PAR receptor within a defined sequence in its extracellular N-terminal domain. This cleavage results in the creation of a new N-terminal sequence (tethered ligand), which subsequently binds to a site in the second extracellular loop of the same receptor. This binding results in the coupling of the receptor to G proteins and in the activation of several signal transduction pathways1-3 Different PARs are activated by different proteinases. PAR-4 is activated by both thrombin and trypsin whereas PAR-1 and PAR-3 are activated by thrombin and PAR-2 is activated by trypsin1-3. PAR-4 can be also cleaved and activated by other proteinases such as cathepsin G. The intracellular signaling mechanisms mediated by PAR-4 activation are not completely elucidated but they may involve calcium mobilization downstream of phospholipase C through the Gαq pathway1-3 Tissue distribution of PAR-4 is very broad with the highest expression levels found in lung, testis, pancreas and small intestine. In addition, PAR-4 expression was observed in platelets, megakaryocytes and leukocytes. Studies with platelets derived form PAR-4 knockout mice have established an essential role for PAR-4 in thrombin-induced platelet activation.PAR-4 is likely involved in other physiological functions such as regulation of gastrointestinal motility and regulation of vascular endothelial cell function1-3.

Supplier: Enzo Life Sciences

p53 activator

Supplier: Enzo Life Sciences

HDAC inhibitor

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

BACE1 is expressed as a pre-pro-aspartyl protease, sometimes glycosylated, and inserted into the cell membrane as a dimer with catalytic domains in the cytosol. It is implicated in angiogenesis and Alzheimer’s disease.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Neurokinin receptor ligand

Supplier: Enzo Life Sciences

S1P receptor ligand.

Supplier: Enzo Life Sciences

Nicotinamide, the water-soluble amide of nicotinic acid, is a component of the two most important coenzymes-nicotinamide adenine dinucleotide and nicotinamide adenine dinucleotide phosphate. Nicotinamide is involved in numerous oxidation-reduction reactions in mammalian biological systems acting as an antioxidant.

Supplier: Enzo Life Sciences

FLUOR DE LYS® Developer II is an essential reagent for signal generation in assays done with the FLUOR DE LYS®-HDAC8, FLUOR DE LYS®-SIRT1 and FLUOR DE LYS®-SIRT2 substrates. Deacetylation of the FLUOR DE LYS® substrate sensitises it so that, in a second step, treatment with the FLUOR DE LYS® Developer II produces a fluorophore. Typically, an ‘inhibitor stop’ will be included in the 1X Developer dilution (e.g. nicotinamide for sirtuins).

Supplier: Enzo Life Sciences

The FLUOR DE LYS®-Succinyl green, desuccinylase substrate offers a highly sensitive and convenient alternative to radiolabeled, succinylated histones or peptide/HPLC methods for the assay of desuccinylases such as SIRT5.