12531 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Two forms of the protein are produced by alternative splicing of the gene - subunits XAPC7-S and XAPC7-L.

Supplier: Enzo Life Sciences

The hybridoma secreting the antibody to subunit β2 was generated by fusion of splenocytes from Balb/c mice which had received repeated immunization with dinitrophenylated proteasomes. The antibody (clone MCP165) has been characterised by one- and two dimensional Western blotting. The antibody has not been demonstrated to immunoprecipitate the native 20S proteasome. The immunoglobulin subclass is IgG1.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Cytosolic calcium (Ca2+) has long been known to act as a key second messenger in many intracellular pathways including synaptic transmission, muscle contraction, hormonal secretion, cell growth and proliferation. The mechanism controlling intracellular Ca2+ level influx either by the calcium-release-activated Ca2+ channels (CRAC), or from intracellular stores, has become of great interest to researchers. Several key players of the store operated complex have been identified; the Orai family consisting of three members, Orai1-3, and the STIM family, which consists of two members, STIM1 and STIM2. Orai1 (also known as CRACM1) acts as the store-operated calcium channel (SOC) and STIM1 as the endoplasmic reticulum Ca2+ sensor3,4. The majority of STIM1 appears to be localized intracellularly at the ER membrane while low expression of STIM1 has been detected on the cell surface of several cell types.

Supplier: Enzo Life Sciences

Produced in E. coli. Human ARH1 is fused at the C-terminus to a His-tag.

Supplier: Enzo Life Sciences

PKG inhibitor

Supplier: Enzo Life Sciences

PKC activator.

Supplier: Enzo Life Sciences

Dopamine receptor ligand.

Supplier: Enzo Life Sciences

Arachidonic acid metabolite.

Supplier: Enzo Life Sciences

Multidrug resistance transporter activator.

Supplier: Enzo Life Sciences

Highly reactive thiol-specific spin label.

Supplier: Enzo Life Sciences

Cell permeable antagonist of L-type Ca2+ channels in C. elegans and vertebrates.

Supplier: Enzo Life Sciences

This kit is useful for assaying lysates, immunoprecipitates or inhibitor screening using the nuclear extract provided. Includes HeLa nuclear extract, a rich source of HDACs 1 & 2 for use as a positive control or as a source of HDAC activity for screening. Compatible with class I & IIb HDAC and sirtuins (with addition of NAD+).

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay System. The MMP-9 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-9 (MMP-9, gelatinase B) using a thiopeptide as a chromogenic substrate.

Supplier: Enzo Life Sciences

A QuantiZyme™ Assay SystemThe MMP-7 Colorimetric Drug Discovery Kit is a complete assay system designed to screen inhibitors of matrix metalloproteinase-7 (MMP-7, matrilysin) using a thiopeptide as a chromogenic substrate.

Supplier: Enzo Life Sciences

The HDAC2 Fluorescent Activity Assay/Drug Discovery Kit is a complete assay system designed to measure the lysyl deacetylase activity of the recombinant human HDAC2 included in the kit. The kit is ideal for chemical library screening for candidate inhibitors or kinetic assay of the enzyme under varying conditions.

Supplier: Enzo Life Sciences

Potent inhibitor of VEGFRs

Supplier: Enzo Life Sciences

Selective inhibitor of JAK1 and JAK2 kinases including the JAK2 V617F mutant

Supplier: Enzo Life Sciences

Inhibitor of PDK1, TBK1, IKK-ε, IRF3

Supplier: Enzo Life Sciences

The Toll-like receptor (TLR) family in mammal comprises a family of transmembrane proteins characterized by multiple copies of leucine rich repeats in the extracellular domain and IL-1 receptor motif in the cytoplasmic domain. Like its counterparts in Drosophila, TLRs signal through adaptor molecules. Toll-like receptor 4 (TLR4), the principal signaling receptor for lipopolysaccharide (LPS) in mammals, requires the binding of MD-2 to its extracellular domain for maximal responsiveness. MD-2 enables TLR4 to respond to a wide variety of LPS partial structures, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, peptidoglycan, and lipopeptide.

Supplier: Enzo Life Sciences

Dimethylargininase (DDAH) is a Cys-hydrolase, which, through catabolism of mono- and dimethylated derivatives of L-arginine, regulates the activity of nitric oxide synthase. DDAH-1 is mainly present in tissues expressing the constitutive forms of nitric oxide synthase such as brain and kidney.

Supplier: Enzo Life Sciences

mTOR (FKBP12-rapamycin associated protein (FRAP)) is one of a family of proteins involved in cell cycle progression, DNA recombination, and DNA damage detection. It has been shown to associate with the immunophilin FKBP12 in a rapamycin-dependent fashion. FKBP12-rapamycin-binding (FRB) domain is a conserved 11kDa region necessary for FKBP12-rapamycin binding. FRB is one of several functional domains of mTOR: HEAT (Huntington elongation factor 1A-protein phosphatase 2A-A subunit-TOR); FAT (FRAP, ATM, TTRAP2); PIKK (PI3-kinase-related kinase); RD (regulatory domain); and FATC (FAT, C terminal).

Supplier: Enzo Life Sciences

Most sensitive ELISA kit, enabling reduced input sample, for the quantification of human haptoglobin, a potent immunosuppressor and stimulator of angiogenesis.

Supplier: Enzo Life Sciences

Rapid ELISA kit to quantify hepsin, a serine protease and unique cancer biomarker.

Supplier: Enzo Life Sciences

Ubiquitin is a 76-amino acid polypeptide expressed in all eukaryotic cells, highly conserved from yeast to humans. The modification of proteins by chains of ubiquitin mediates targeting of cytosolic and nuclear proteins for degradation by proteasomes. Ubiquitination represents an essential cellular process affected by a multi-enzyme cascade involving classes of enzymes known as ubiquitin-activating enzymes (E1s), ubiquitin-conjugating enzymes (E2s or Ubcs) and ubiquitin-protein ligases (E3s). E1 activates ubiquitin in an ATP-dependent manner with the formation of a thiol-ester linkage between the carboxy terminus of ubiquitin and E1. Sequential, transient thiol-ester bonds then generate between the carboxyl terminus of ubiquitin and specific cysteines of E2 and E3 enzymes. These bonds culminate in the formation of an isopeptide linkage between the activated carboxy terminus of ubiquitin and the epsilon-amino group of a lysine on a target protein, or within another ubiquitin chain (usually K48 of ubiquitin) resulting in the generation of chains of ubiquitin (polyubiquitin or multiubiquitin) from 4-20 ubiquitin moieties. Although the formation of K48-linked polyubiquitin chains on proteins constitutes a potent targeting signal for degradation in 26S proteasomes, ubiquitination is also reversible, and a number of not fully characterized deubiquitinating enzymes exist free in the cytosol. Research exploring how proteasome targets ER-retained proteins for degradation suggests that ER chaperones (such as Cne1p/calnexin, Kar2p/BiP or other components of the protein processing or transport machineries) helped by cytosolic chaperones (such as members of the Hsp70 and DnaJ families) recognize, target and force misfolded, unassembled or aberrantly modified proteins through the translocon. The retrotranslocated polypeptide chains are then released into the cytosol as soluble proteins or remain adhered to the cytosolic face of the ER membrane where deglycosylation and polyubiquitination followed by binding to the proteasome as well as degradation to peptides occurs. Ubiquitination also participates in the internalization and degradation of plasma membrane proteins such as some of the TCR subunits while still ER-membrane associated.

Supplier: Enzo Life Sciences

PARP inhibitor

Supplier: Enzo Life Sciences

Orally bioavailable 284 D-1,2,4-oxadiazole.

Supplier: Enzo Life Sciences

Necroptosis inhibitor

Supplier: Enzo Life Sciences

Necroptosis inhibitor