5862 Results for: "ENZO LIFE SCIENCES"

Supplier: Enzo Life Sciences

Cell permeable inhibitor of RhoA- and RhoC-mediated signaling. Inhibits LPA-induced DNA synthesis in PC-3 prostate cancer cell lines (<1µM) and inhibits the growth of RhoC-overexpressing melanoma cell lines (A375M2 and SK-Mel-147) at nanomolar concentrations.

Supplier: Enzo Life Sciences

Hepatotoxic and hepatocarcinogenic mycotoxin.

Supplier: Enzo Life Sciences

Blocks methyl esterification of geranylgeranylated proteins

Supplier: Enzo Life Sciences

Quinone antioxidant.

Supplier: Enzo Life Sciences

Fluorogenic substrate for TACE (ADAM17) (between Ala-Val), as well as MMP-3, MMP-7, MMP-12, and MMP-17, but not for ADAM19, MMP-13, nor MMP-14. Similar substrates are also cleaved by ADAM10, ADAM8 and ADAM9, and MMP-1, -2, and -9. This quenched substrate is useful for TACE inhibitor screening and kinetic analysis. Ex: 328 nm, Em: 393 nm, although the following Ex/Em have been used: 320-340/400-420. Also available: OMNIMMP® Fluorogenic Control peptide (BML-P127).

Supplier: Enzo Life Sciences

ACE substrate

Supplier: Enzo Life Sciences

Olomoucine is a purine derivative which acts as a potent and selective inhibitor of CDK1 (p34cdc2)/cyclin B and related kinases. It acts by competing for the ATP binding domain of the kinase. Of 35 protein kinases tested, olomoucine inhibited p33CDK2/cyclin A, p33CDK2/cyclin E, p34cdc2/cyclin B, p33CDK5/p35 and erk1 with IC50 of 7, 7, 7, 3 and 25µM respectively. The related kinases p34CDK4/cyclin D and p40CDK6/cyclin D3 were not inhibited or were less sensitive to olomoucine, IC50 > 1000 and 250µM respectively. PKC, PKA, PKG, CaM kinase II, MLC kinase, CK2, EGFR tyrosine kinase, p56lck, p56lyn, p60c-src, v-abl and insulin receptor tyrosine kinase are not inhibited or are weakly inhibited at 1mM. It delays mouse oocyte maturation and inhibits the growth of a variety of human cell lines including Rhabdomyosarcoma cell line Rh1, Rh18, Rh28 and Rh30; MCF-7, KB-3-1 and their adriamycin-resistant counterparts (IC50=18-86µM). It inhibits DNA synthesis in interleukin-2-stimulated T lymphocytes and triggers a G1 arrest similar to interleukin-2 deprivation. Can be used to synchronize cells in G1. Triggers apoptosis in target tumor cells in vitro and in vivo and in maturing cerebellar granule neurons. N9-Isopropyl-olomoucine and the negative control Iso-olomoucine are also available.

Supplier: Enzo Life Sciences

Inhibits ATP-sensitive K+ channels.

Supplier: Enzo Life Sciences

PKC inhibitor

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

BCRP inhibitor

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

The EFLUXX-ID® Multidrug Resistance Assay Kit allows for functional detection of all three clinically relevant ABC transporter proteins MDR1 (p-glycoprotein), MRP1/2, and BCRP. The assay uses a hydrophobic, non-fluorescent compound that readily penetrates the cell membrane, where it is hydrolyzed to a hydrophilic fluorescent dye by intracellular esterases.

Supplier: Enzo Life Sciences

Recommended Applications: Flow Cytometry, IHC (PS)

Species reactivity: Human

Supplier: Enzo Life Sciences

Inhibits α-mannosidase. Inhibits asparagine-linked oligosaccharide processing. Immunomodulator.

Supplier: Enzo Life Sciences

Host: Rabbit

Supplier: Enzo Life Sciences

Natural source of phorbol and phorbol esters.

Supplier: Enzo Life Sciences

Colorimetric kit for the determination of cytotoxicity through the measurement of lactate dehydrogenase activity.

Supplier: Enzo Life Sciences

The PATHO-GENE® HPV screening probe is a mixture of biotin-labeled HPV 6, HPV 11, HPV16, HPV 18, HPV 31, HPV 33, and HPV 51-specific probes in buffered formamide and hybridisation enhancers.

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Mouse, Isotype: IgG1

Supplier: Enzo Life Sciences

Host: Rat, Isotype: IgG2a

Supplier: Enzo Life Sciences

Geranylgeranylpyrophosphate precursor and apoptosis inducer.

Supplier: Enzo Life Sciences

Retinoic acid receptor ligand

Supplier: Enzo Life Sciences

All members of the inhibitor of apoptosis proteins (IAP) family contain at least one, but usually three copies of baculovirus IAP repeat (BIR), a ~70-aa zinc binding domain, and upon overexpression suppress apoptosis. The BIR motif is capable of interacting with caspases and occluding their catalytic pockets. Certain IAPs also possess C-terminal RING domains. RING-containing proteins often act as E3 ubiquitin ligases and can catalyse the degradation of both, themselves and selected target proteins through ubiquitylation. So far, eight human IAPs have been identified: Apollon (Bruce), c-IAP1 (HIAP2; MIHB), c-IAP2 (HIAP1; MIHC), ILP-2 (Ts-IAP), Livin (ML-IAP; KIAP), NAIP, Survivin (TIAP) and XIAP (ILP-1; MIHA). c-IAP1 has been shown to inhibit specific caspases.

Supplier: Enzo Life Sciences

Produced in E.coli.

Supplier: Enzo Life Sciences

Nitric oxide (NO) donor.

Supplier: Enzo Life Sciences

Most efficient spin trap for the in vitro and in vivo detection of O-, N-, S-, and C-centered free radicals.

Supplier: Enzo Life Sciences

Isolated from bovine brain.

Supplier: Enzo Life Sciences

Fixation/Permeabilization, (buffer)