Anti-CD184 (CXCR4) Mouse Monoclonal Antibody [clone: 12G5] (APC)

Supplier: STEMCELL Technologies

Certificates

Supplier: STEMCELL Technologies

About this item

Mouse monoclonal IgG2a antibody against human, rhesus, cynomolgus CD184 (CXCR4), APC-conjugated.

Endoderm Psc Derived
Pluripotent Stem cells

The 12G5 antibody reacts with CD184 (CXCR4 or fusin), an ~45 kDa seven transmembrane G-protein-coupled receptor expressed on the surface of a broad range of cells, including T and B cells, dendritic cells, monocytes, macrophages, granulocytes, platelets, endothelial and epithelial cells, astrocytes and neurons. At least two isoforms of CD184 are generated by alternate mRNA splicing. Ligands for CD184 include the CXC chemokine SDF-1 and ubiquitin. CD184 has functional roles in mediating chemotaxis, B cell lymphopoiesis and myelopoiesis, cardiogenesis, vascularization and neuronal guidance. CD184 acts as a co-receptor for infection by some T cell-tropic isolates of HIV-1 and as an alternative receptor for CD4-independent infection by HIV-2; functions that are blocked by binding of the 12G5 antibody. The antibody also partially inhibits SDF-1-induced chemotaxis and calcium influx. In differentiation studies, CD184 is used along with other markers such as CD117 to monitor the emergence of definitive endoderm.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: CD184 (CXCR4)
Clonality: Monoclonal
Clone: 12G5
Conjugation: APC
Epitope:
Host: Mouse
Isotype: IgG2a kappa
Reactivity: African green monkey;Baboon;Chimpanzee;Cynomolgus monkey;Human;Rhesus monkey;Sooty mangabey

Specifications

Catalog No:
STMC60089AZ
STMC60089AZ.1

Antigen name:
CD184 (CXCR4)
CD184 (CXCR4)

Clonality:
Monoclonal
Monoclonal

Conjugation:
APC (Allophycocyanin)
APC (Allophycocyanin)

Clone:
12G5
12G5

Reactivity:
Baboon, African green monkey, Cynomolgus monkey, Sooty mangabey, Rhesus monkey, Chimpanzee, Human
Baboon, African green monkey, Cynomolgus monkey, Sooty mangabey, Rhesus monkey, Chimpanzee, Human