Anti-Perforin Mouse Monoclonal Antibody [clone: deltaG9]

Catalog # STMC100-1457

Supplier: STEMCELL Technologies

Catalog # STMC100-1457

Supplier: STEMCELL Technologies

Specifications

Antigen name:
Perforin
Clonality:
Monoclonal
Clone:
deltaG9
Conjugation:
Unconjugated
Host:
Mouse
Isotype:
IgG2b kappa
Reactivity:
Human
Environmentally Preferable:
Gene ID:
5551
Pk:
100 µG

Specifications

About this item

Mouse monoclonal antibody against human perforin, unconjugated.

Nk cells
T cells CD8

This mouse monoclonal antibody (clone deltaG9) reacts with human perforin. Perforin is an ~70 kDa protein consisting of four domains: the N- and C-termini, which are related to its function, and two central domains that share similarities to complement proteins C6 - C9. Perforin is involved in the perforin/granzyme apoptosis pathway and is produced by natural killer and cytotoxic T cells. Upon contact with a target cell, perforin monomers are released and aggregate to form pores in the membrane of the target cell, disrupting its membrane integrity. This allows granzyme B to enter the target cell and initiate apoptosis of virally infected and transformed cells.

Caution: Product restrictions: (i) Customer shall not make products or any portion of them in any way, shape or form, including as a component of another product available for the purpose of further resale or alter or remove the Product label and the Supplier’s mark of origin without express written permission of Supplier and (ii) Customer is familiar with Supplier’s restrictions on the use of the products and shall use the products in compliance with such restrictions and the applicable Supplier Product Information sheet (collectively, the 'Product Restrictions').

Type:
Antigen: Perforin
Clonality: Monoclonal
Clone: deltaG9
Conjugation: Unconjugated
Epitope:
Host: Mouse
Isotype: IgG2b kappa
Reactivity: Human