Specifications
- Antibody type:Primary
- Antigen name:HIF-1 Alpha
- Clonality:Polyclonal
- Conjugation:Alexa Fluor® 680
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Rabbit,Human,Rat,Mouse
- Western blot:Yes
- Epitope:341-450/826
- Form:Liquid
- Gene ID:3091
- Antigen synonyms:PASD8|HIF-1alpha|HIF1A|HIF1-ALPHA|HIF-1A|HIF1|PAS domain-containing protein 8|MOP1|Hypoxia-inducible factor 1-alpha|ARNT-interacting protein|Basic-helix-loop-helix-PAS protein MOP1|HIF-1-alpha|bHLHe78|Member of PAS protein 1|Class E basic helix-loop-helix protein 78
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:92 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human of human HIF-1 Alpha
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
Functions as a master transcriptional regulator of the adaptive response to hypoxia. Under hypoxic conditions, activates the transcription of over 4 genes, including erythropoietin, glucose transporters, glycolytic enzymes, vascular endothelial growth factor, HILPDA, and other genes whose protein products increase oxygen delivery or facilitate metabolic adaptation to hypoxia. Plays an essential role in embryonic vascularization, tumor angiogenesis and pathophysiology of ischemic disease. Binds to core DNA sequence 5'-[AG]CGTG-3' within the hypoxia response element (HRE) of target gene promoters. Activation requires recruitment of transcriptional coactivators such as CREBPB and EP3. Activity is enhanced by interaction with both, NCOA1 or NCOA2. Interaction with redox regulatory protein APEX seems to activate CTAD and potentiates activation by NCOA1 and CREBBP. Involved in the axonal distribution and transport of mitochondria in neurons during hypoxia.
Type: Primary
Antigen: HIF-1 Alpha
Clonality: Polyclonal
Clone:
Conjugation: ALEXA FLUOR® 680
Public Immunogen Range: 341-450/826
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat, Rabbit, Others