Specifications
- Antibody type:Primary
- Antigen name:HEXO
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Host:Rabbit
- ImmunoChemistry:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Reactivity:Mouse
- Epitope:51-150/349
- Form:Liquid
- Gene ID:90459
- Antigen synonyms:ERI1|Histone mRNA 3'-exonuclease 1|Histone mRNA 3'-end-specific exoribonuclease|Eri-1 homolog|3'-5' exoribonuclease 1|3'EXO|3'HEXO|HEXO|THEX1|Protein 3'hExo|3'-5' exonuclease ERI1
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:40 kDa
- Storage temperature:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Shipping temperature:4 °C
- Immunogen:KLH conjugated synthetic peptide derived from human HEXO
- Tested applications:ICC
- Purification:Purified by Protein A
- Pack type:Vial
- Pk:100 µl
Specifications
About this item
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5,8S rRNA 3'-end processing. Also binds to 5,8S ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Type: Primary
Antigen: HEXO
Clonality: Polyclonal
Clone:
Conjugation: FITC
Public Immunogen Range: 51-150/349
Host: Rabbit
Isotype: IgG
Reactivity: Mouse