Specifications
- Type d'anticorps:Primaire
- Nom de l'antigène:HEXO
- Clonalité:Polyclonal
- Conjugaison:Cy3®
- Hôte:Rabbit
- ImmunoChimie:Yes
- ImmunoFluorescence:Yes
- Isotype:IgG
- Réactivité:Mouse
- Épitope:51-150/349
- Formulaire:Liquid
- ID de gène:90459
- Synonymes antigène:ERI1|Histone mRNA 3'-exonuclease 1|Histone mRNA 3'-end-specific exoribonuclease|Eri-1 homolog|3'-5' exoribonuclease 1|3'EXO|3'HEXO|HEXO|THEX1|Protein 3'hExo|3'-5' exonuclease ERI1
- Modification:Unmodified
- Storage buffer:Aqueous buffered solution containing 0,01 M TBS (pH 7,4) with 1% BSA, 0,03% Proclin300 and 50% Glycerol
- Molecular weight:40 kDa
- Température de stockage:Store at –20 °C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
- Concentration:1 µg/µl
- Température de transport:4 °C
- Immunogène:KLH conjugated synthetic peptide derived from human HEXO
- Tested applications:ICC
- Purification:Purified by Protein A
- Type de conditionnement:Vial
- Cdt:100 µl
Specifications
About this item
RNA exonuclease that binds to the 3'-end of histone mRNAs and degrades them, suggesting that it plays an essential role in histone mRNA decay after replication. A 2' and 3'-hydroxyl groups at the last nucleotide of the histone 3'-end is required for efficient degradation of RNA substrates. Also able to degrade the 3'-overhangs of short interfering RNAs (siRNAs) in vitro, suggesting a possible role as regulator of RNA interference (RNAi). Requires for binding the 5'-ACCCA-3' sequence present in stem-loop structure. Able to bind other mRNAs. Required for 5,8S rRNA 3'-end processing. Also binds to 5,8S ribosomal RNA. Binds with high affinity to the stem-loop structure of replication-dependent histone pre-mRNAs.
Type: Primary
Antigen: HEXO
Clonality: Polyclonal
Clone:
Conjugation: Cy3
Public Immunogen Range: 51-150/349
Host: Rabbit
Isotype: IgG
Reactivity: Mouse