Detects low copy number target and withstands PCR inhibitors without extensive purification.

• Robust amplification of genomic DNA targets up to 10 kb
• High-specificity HotStart increases enzyme sensitivity
• Superior efficiency and yield with our patented ArchaeMaxx polymerase-enhancing factor
• Mixed ends

The PicoMaxx High-Fidelity PCR System detects low copy number targets in complex DNA backgrounds, amplifies difficult systems with minimal nonspecific amplification, and works with PCR applications that require prolonged incubations at room temperature prior to thermal cycling. Its robustness withstands effects of PCR inhibitors without the need for extensive purification and subsequent DNA loss. The system is formulated with antibodies that inhibit polymerase activity until cycling begins, promoting high-specificity and reduced background. This formulation is ideal for high-throughput, multi-target amplification experiments.

The ArchaeMaxx advantage improves the yield of products by overcoming dUTP poisoning, which is caused by dUTP accumulation during PCR through dCTP deamination. Once incorporated, dU-containing DNA inhibits the enzyme and the ArchaeMaxx factor functions as a dUTPase, converting poisonous dUTP to harmless dUMP and inorganic pyrophosphate. PicoMaxx reliably produces high PCR product yields on a wide variety of templates up to 10 kb.