Inhibits NF-kappaB translocation

Sequence contains the nuclear localization sequence (NLS residues 360-369) of the transcription factor NF-kappaB p50 linked to a peptide cell-permeablization sequence, the hydrophobic region (h-region) of the signal peptide of Kaposi fibroblast growth factor (K-FGF). Peptide inhibits translocation of the NF-kappaB active complex into the nucleus. In mouse endothelial LE-II cells induced with LPS, inhibition of NF-kappaB nuclear translocation was 88% at 50 µg/ml (18 µM). In human monocytic THP-1 cells induced by LPS or TNFalpha there was 85% inhibition at 100 µg/ml. Sold under license from Vanderbilt University.