Human recombinant IL-35:Fc
Catalog # ENZOALX522140C010
Supplier: ENZO LIFE SCIENCES
CAS Number:
Specifications
- Pk:10 µG
- Protein/peptide type:Recombinant
- Species:Human
- Seq:02
- Biological activity:Inhibits human mononuclear cell proliferation.
- Reconstitution instructions:Reconstitute with 100 µl sterile water. Further dilutions should be made with medium containing 5% fetal calf serum or a carrier protein.
- Protein/peptide name:IL-35:Fc
- Purity:>95% (SDS-PAGE)
- Concentration:0,1 mg/ml after reconstitution
- Formulation:Lyophilised. Contains PBS.
Specifications
About this item
Produced in HEK 293 cells. Human EBI3 (aa 21-229) linked to human IL-12A (aa 23-219) via the linker GGGSGGGSGGGSGGGS is fused at the C-terminus to the Fc portion of human IgG1 and a FLAG®-tag.
EBI3 (Epstein-Barr virus-induced gene 3 protein; EBV-induced gene 3 protein; IL-27B; IL-27 subunit β) and IL-12A (IL-12 subunit p35; CLMF p35) form the heterodimeric cytokine IL-35 (interleukin-35) involved in T cell regulation.
IL-35 is highly expressed in regulatory T cell (Treg) but not in effector or naive T cells. IL-35 is required for the suppressive function of T-reg in vitro and in vivo.