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Human recombinant B Lymphocyte Kinase (from E. coli)
Human recombinant B Lymphocyte Kinase (from E. coli)
  PRSI92-107
 :  
Human recombinant B Lymphocyte Kinase (from E. coli)
  PRSI92-107
 :  

 

  • Pk:
    50 µG
  • Enzyme type:
    Recombinant
  • Source:
    E. coli
  • Species:
    Human
  • Tag sequence:
    C-6 His tag
  • Storage conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
  • Enzyme name:
    B Lymphocyte Kinase
  • Purity:
    >95% as determined by reducing SDS-PAGE
  • Molecular weight:
    58.7 kD
  • Sequence:
    Gly2-Pro505
  • Formulation:
    Supplied as a 0.2 µm filtered solution of 20 mM Tris, 500 mM NaCl, 1 mM DTT, pH 7.4. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH₂O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

 

 

Tyrosine-Protein Kinase Blk (BLK) contains one protein kinase domain, one SH2 domain and one SH3 domain. BLK is a non-receptor tyrosine kinase, which is involved in B-lymphocyte development, differentiation and signaling. B-cell receptor (BCR) signaling requires a tight regulation of several protein tyrosine kinases and phosphatases, and associated coreceptors. Signaling through BLK plays an important role in transmitting signals through surface immunoglobulines and supports the pro-B to pre-B transition, as well as the signaling for growth arrest and apoptosis downstream of B-cell receptor. Defects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11).

Fusion-Tag: C-6 His tag

This recombinant protein can be used for biological assays. For research use only.