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Human recombinant sorbitol dehydrogenase (from cells)
Human recombinant sorbitol dehydrogenase (from cells)
  PRSI91-671
 :  ProSci Inc.
 :  
Human recombinant sorbitol dehydrogenase (from cells)
  PRSI91-671
 :  ProSci Inc.
 :  

 

  • Pk:
    50 µG
  • Enzyme type:
    Recombinant
  • Source:
    Cells
  • Species:
    Human
  • Tag sequence:
    C-6 His tag
  • Storage conditions:
    Store at −20 °C, stable for 6 months after receipt. Please minimize freeze−thaw cycles.
  • Enzyme name:
    Sorbitol Dehydrogenase
  • Purity:
    >95% as determined by reducing SDS-PAGE
  • Molecular weight:
    39.3 kD
  • Sequence:
    Ala2-Pro357
  • Formulation:
    Supplied as a 0.2 µm filtered solution of 20 mM TrisHCl,0.2 M NaCl,5mM DTT, 20% glycerol,pH 8.0. Always centrifuge tubes before opening. Do not mix by vortex or pipetting. It is not recommended to reconstitute to a concentration less than 100 ug/ml. Dissolve the lyophilized protein in ddH2O. Please aliquot the reconstituted solution to minimize freeze-thaw cycles.
  • Tested applications:
    Bioassay

 

 

Sorbitol dehydrogenase, also known as L-iditol 2-dehydrogenase and SORD, is a member of the zinc-containing alcohol dehydrogenase family. SORD exsits in a homotetramer and binds one zinc ion per subunit. SORD is expressed in kidney and epithelial cells of both benign and malignant prostate tissue. SORD can converts sorbitol to fructose and catalyses the interconversion of polyols and their corresponding ketoses, and together with aldose reductase to make up the sorbitol pathway. SORD is up-regulated by androgens and down-regulated by castration. SORD may play a role in the sperm motility by providing an energetic source for sperm.

Fusion-Tag: C-6 His tag

This recombinant protein can be used for biological assays. For research use only.