Mouse recombinant B7-H4 (from CHO cells)
Catalog # PRSI90-371
Supplier: ProSci Inc.
CAS Number:
Specifications
- Pk:100 µG
- Protein/peptide type:Recombinant
- Source:CHO cells
- Species:Mouse
- Tag sequence:Fc Tag
- Storage conditions:Stable for at least 1 year after receipt when stored at −20 °C. Working aliquots are stable for up to 3 months when stored at −20 °C.
- Biological activity:Measured by its ablility to inhibit anti-CD3-induced proliferation of stimulated mouse T cells.
- Protein synonyms:Immune Costimulatory Protein B7-H4|V-set Domain-containing T Cell Activation Inhibitor 1|B7h.5|Protein B7S1|VTCN1|T Cell Costimulatory Molecule B7x
- Protein/peptide name:B7-H4
- Purity:>98% (SDS-PAGE)
- Sequence:29-258
- Formulation:Lyophilized from 0.2um-filtered solution in PBS.
Specifications
About this item
B7-H4 is a B7 family member that negatively regulates T cell immunity by inhibiting T cell proliferation, cytokine production and cell cycle progression. In vitro, B7-H4 inhibits CD4+ and CD8+ T cell proliferation, cytokine production and generation of alloreactive cytotoxic T cells (CTLs). In vivo, blockade of endogenous B7-H4 by specific monoclonal antibody promotes T cell responses. B7-H4 ia an important negative regulator of innate immunity through growth inhibition of neutrophils. B7-H4 is expressed on some tumour cancer cells. The role of B7-H4 in tumour progression may be to transform precancerous cells and then protect them from immunosurveillance.
- This recombinant proteins is for research use only.
Fusion-Tag: Fc Tag
This recombinant proteins is for research use only.