Human recombinant NGF beta (from E. coli)
Catalog # PRSI40-572
Supplier: ProSci Inc.
CAS Number:
Specifications
- Pk:100 µG
- Protein/peptide type:Recombinant
- Source:E. coli
- Species:Human
- Biological activity:Determined by the dose-dependent stimulation of the proliferation of human TF-1 cells. The expected ED50 is ≤ 1.0 ng/mL, corresponding to a specific activity of ≥ 1 x 106 units/mg.
- Protein synonyms:HSAN5|Beta-NGF|Beta-nerve growth factor|NGFB
- Protein/peptide name:NGF beta
- Purity:>98%
- Formulation:Lyophilized
Specifications
About this item
Beta-NGF is a neurotrophic factor structurally related to BDNF, NT-3 and NT-4. These proteins belong to the cysteine-knot family of growth factors that assume stable dimeric structures. Beta-NGF is a potent neurotrophic factor that signals through its receptor Beta-NGFR, and plays a crucial role in the development and preservation of the sensory and sympathetic nervous systems. Beta-NGF also acts as a growth and differentiation factor for B lymphocytes and enhances B-cell survival. The functional form of human Beta-NGF is a noncovalently disulfide-linked homodimer, of two 13.5 kDa polypeptide monomers (238 total amino acid residues). The three disulfide bonds are required for biological activity.Manufactured using all non-animal reagents.
- Store in working aliquots at -20°C. Avoid freeze/thaw cycles.