Specifications
- Antibody type:Primary
- Antigen name:KIT ligand
- Antigen symbol:KITLG
- Clonality:Polyclonal
- Conjugation:FITC (Fluorescein Isothiocyanate)
- Flow cytometry:Yes
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:4254
- Antigen synonyms:Kit ligand|SCF|KL-1|Kitl|Stem cell factor precursor|SF|FPH2|Mast cell growth factor|MGF|SHEP7|KIT ligand
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:160-210/273
- Purification:Purified by Protein A
- Pk:100 µl
Specifications
About this item
Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.
Recommended Dilutions: Flow Cytometry: 1:20-100; IF(IHC-P): 1:50-200; IF(IHC-F)(1:50-200
Type: Primary
Antigen: KITLG
Clonality: Polyclonal
Clone:
Conjugation: FITC (Fluorescein Isothiocyanate)
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat